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Polyphenol-Assisted Chemical Crosslinking: A New Strategy to Achieve Highly Crosslinked, Antioxidative, and Antibacterial Ultrahigh-Molecular-Weight Polyethylene for Total Joint Replacement
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-22 , DOI: 10.1021/acsbiomaterials.0c01437
Yue Ren 1 , Fei-Yu Wang 2 , Ri-Tong Lan 1 , Wan-Qun Fu 2 , Zi-Jian Chen 2 , Hao Lin 1 , Shishu Huang 3 , Rizwan M. Gul 4 , Jing Wang 2 , Jia-Zhuang Xu 1 , Zhong-Ming Li 1
Affiliation  

Highly crosslinked ultrahigh-molecular-weight polyethylene (UHMWPE) bearings are wear-resistant to reduce aseptic loosening but are susceptible to oxidize in vivo/in vitro, as reported in clinical studies. Despite widespread acceptance of antioxidants in preventing oxidation, the crosslinking efficiency of UHMWPE is severely impacted by antioxidants, the use of which was trapped in a trace amount. Herein, we proposed a new strategy of polyphenol-assisted chemical crosslinking to facilitate the formation of a crosslinking network in high-loaded tea polyphenol/UHMWPE blends. Epigallocatechin gallate (EGCG), a representative of tea polyphenol, was mixed with UHMWPE and peroxide. Multiple reactive phenolic hydroxyl groups of tea polyphenol coupled with the nearby free radicals to form extra crosslinking sites. The crosslinking efficiency was remarkably enhanced with increasing tea polyphenol content, even at a concentration of 8 wt %. Given by the hydrogen donation principle, the high-loaded tea polyphenol also enhanced the oxidation stability of the crosslinked UHMWPE. The antioxidative performance was preserved even after tea polyphenol elution. Moreover, superior antibacterial performance was achieved by the in situ tea polyphenol release from the interconnected pathways in the present design. The strategy of polyphenol-assisted chemical crosslinking is applicable for producing highly crosslinked, antioxidative, and antibacterial UHMWPE, which has promising prospects in clinical applications.

中文翻译:

多酚辅助化学交联:实现完全交联置换的高交联,抗氧化和抗菌超高分子量聚乙烯的新策略

如临床研究中所述,高度交联的超高分子量聚乙烯(UHMWPE)轴承具有耐磨性,可减少无菌性松动,但在体内/体外易被氧化。尽管抗氧化剂被广泛接受以防止氧化,但UHMWPE的交联效率却受到抗氧化剂的严重影响,抗氧化剂的使用被困在痕量之中。在这里,我们提出了一种多酚辅助化学交联的新策略,以促进高负荷茶多酚/ UHMWPE共混物中交联网络的形成。茶多酚的代表表没食子儿茶素没食子酸酯(EGCG)与UHMWPE和过氧化物混合。茶多酚的多个反应性酚羟基与附近的自由基偶联形成额外的交联位点。甚至在浓度为8 wt%时,交联效率也随着茶多酚含量的增加而显着提高。通过氢供体原理,高负载茶多酚还增强了交联的UHMWPE的氧化稳定性。即使在茶多酚洗脱后,抗氧化性能也得以保留。此外,在本设计中,通过从相互连接的路径中就地释放茶多酚可实现卓越的抗菌性能。多酚辅助化学交联策略可用于生产高度交联,抗氧化和抗菌的UHMWPE,在临床应用中具有广阔的前景。高负荷的茶多酚还增强了交联的UHMWPE的氧化稳定性。即使在茶多酚洗脱后,抗氧化性能也得以保留。此外,在本设计中,通过从相互连接的路径中就地释放茶多酚可实现卓越的抗菌性能。多酚辅助化学交联策略可用于生产高度交联,抗氧化和抗菌的UHMWPE,在临床应用中具有广阔的前景。高负荷的茶多酚还增强了交联的UHMWPE的氧化稳定性。即使在茶多酚洗脱后,抗氧化性能也得以保留。此外,在本设计中,通过从相互连接的路径中就地释放茶多酚可实现卓越的抗菌性能。多酚辅助化学交联策略可用于生产高度交联,抗氧化和抗菌的UHMWPE,在临床应用中具有广阔的前景。
更新日期:2021-01-11
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