Abstract

Purpose

The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients.

Method

Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (control group) of 25 healthy individuals were included in this prospective study. A specular microscopy was used to measure corneal endothelial cell density (ECD), percentage of hexagonal cells (HEX%), coefficient of variation of the cell size (CV). Then, a Pentacam® HR corneal tomography system was used to measure central corneal thickness (CCT), corneal aberrometry values in 6-mm pupil diameters and corneal densitometry values in 6-mm corneal zones (0–2 mm and 2–6 mm).

Results

While ECD was significantly lower in the study group than in the control group (p = 0.034), CCT was significantly higher in the study group (p = 0.032). The higher-order aberrations values and the anterior corneal densitometry values in the 0–2 mm and 2–6 mm corneal zones in the study group were found to be significantly higher than the control group (p = 0.021, p = 0.007 and p = 0.013).

Conclusion

Prolonged use of HQ may cause some changes in the cornea. In the follow-up of these cases, detailed examination of the cornea as well as the macula may be important for the protection of corneal health.

中文翻译：

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系统性红斑狼疮患者接受长期羟氯喹治疗的角膜安全性评价

摘要

目的

本研究的目的是检查长期使用羟氯喹 (HQ) 对狼疮患者角膜和角膜内皮的厚度测量、像差测量和光密度测量值的影响。

方法

本前瞻性研究纳入了 22 名使用 HQ 治疗狼疮的患者的 22 只眼（研究组）和 25 名健康个体的 25 只眼（对照组）。镜面显微镜用于测量角膜内皮细胞密度 (ECD)、六角形细胞百分比 (HEX%)、细胞大小变异系数 (CV)。然后，使用 Pentacam® HR 角膜断层扫描系统测量中央角膜厚度 (CCT)、6 毫米瞳孔直径的角膜像差测量值和 6 毫米角膜区域（0-2 毫米和 2-6 毫米）的角膜密度测量值.

结果

研究组的ECD显着低于对照组（p  = 0.034），而研究组的CCT显着高于对照组（p  = 0.032）。研究组 0~2 mm 和 2~6 mm 角膜区的高阶像差值和前角膜光密度值显着高于对照组（p  = 0.021, p  = 0.007 和p  = 0.013)。

结论

长时间使用 HQ 可能会导致角膜发生一些变化。在这些病例的随访中，角膜和黄斑的详细检查可能对保护角膜健康很重要。