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Clustering of desmosomal cadherins by desmoplakin is essential for cell‐cell adhesion
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-12-22 , DOI: 10.1111/apha.13609
Marie-Therès Wanuske 1, 2 , Dominique Brantschen 1 , Camilla Schinner 1, 2 , Chiara Stüdle 1 , Elias Walter 2 , Matthias Hiermaier 1, 2 , Franziska Vielmuth 2 , Jens Waschke 2 , Volker Spindler 1, 2
Affiliation  

Desmoplakin (Dp) is a crucial component of the desmosome, a supramolecular cell junction complex anchoring intermediate filaments. The mechanisms how Dp modulates cell‐cell adhesion are only partially understood. Here, we studied the impact of Dp on the function of desmosomal adhesion molecules, desmosome turnover and intercellular adhesion.

中文翻译:

桥粒蛋白对桥粒钙粘蛋白的聚类对细胞间粘附至关重要

桥粒蛋白 (Dp) 是桥粒的重要组成部分,桥粒是一种锚定中间丝的超分子细胞连接复合物。Dp 调节细胞间粘附的机制仅被部分了解。在这里,我们研究了 Dp 对桥粒粘附分子、桥粒周转和细胞间粘附功能的影响。
更新日期:2020-12-22
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