In vivo biochemical assessment of cartilage with gagCEST MRI: Correlation with cartilage properties,NMR in Biomedicine

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In vivo biochemical assessment of cartilage with gagCEST MRI: Correlation with cartilage properties
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-12-22 , DOI: 10.1002/nbm.4463
Sander Brinkhof ₁ , Razmara Nizak ₂ , Sotcheadt Sim ₃ , Vitaliy Khlebnikov ₁ , Eric Quenneville ₃ , Martin Garon ₃ , Dennis W J Klomp ₁ , Daniel Saris _{2,

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Affiliation

To assess articular cartilage in vivo, a noninvasive measurement is proposed to evaluate damage of the cartilage. It is hypothesized that glycosaminoglycan chemical exchange saturation transfer (gagCEST) can be applied as a noninvasive imaging technique as it would relate to electromechanical indentation and GAG content as measured with biochemical assays. This pilot study applies gagCEST MRI in total knee arthroplasty (TKA) patients to assess substantially damaged articular cartilage. The outcome was verified against electromechanical indentation and biochemical assays to assess the potential of gagCEST MRI. Five TKA patients were scanned on a 7.0 T MRI with a gagCEST sequence. Articular resurfacing cuts after TKA were obtained for electromechanical and biochemical analyses. The gagCEST MRI measurements on the medial condyle showed a moderate correlation with the GAG content, although sensitivity on the lateral condyle was lacking. Additionally, a strong negative correlation of gagCEST MRI with the electromechanical measurements was observed in the regression analysis. Correlation of gagCEST MRI with electromechanical measurements was shown, but the correlation of gagCEST MRI with GAG content was not convincing. In conclusion, gagCEST could be a useful tool to assess the GAG content in articular cartilage noninvasively, although the mismatch in heterogeneity requires further investigation.

中文翻译：

使用 gagCEST MRI 对软骨进行体内生化评估：与软骨特性的相关性

为了在体内评估关节软骨，提出了一种无创测量来评估软骨的损伤。据推测，糖胺聚糖化学交换饱和转移 (gagCEST) 可以作为一种非侵入性成像技术应用，因为它与机电压痕和用生化分析测量的 GAG 含量有关。这项初步研究将 gagCEST MRI 应用于全膝关节置换术 (TKA) 患者，以评估严重受损的关节软骨。结果针对机电压痕和生化分析进行了验证，以评估 gagCEST MRI 的潜力。使用 gagCEST 序列在 7.0 T MRI 上扫描了五名 TKA 患者。获得 TKA 后的关节表面重修切口用于机电和生化分析。内侧髁上的 gagCEST MRI 测量显示与 GAG 含量有中等相关性，尽管对外侧髁缺乏敏感性。此外，在回归分析中观察到 gagCEST MRI 与机电测量的强烈负相关。显示了gagCEST MRI 与机电测量的相关性，但gagCEST MRI 与GAG 含量的相关性并不令人信服。总之，gagCEST 可能是一种有用的工具来无创评估关节软骨中的 GAG 含量，尽管异质性的不匹配需要进一步调查。显示了gagCEST MRI 与机电测量的相关性，但gagCEST MRI 与GAG 含量的相关性并不令人信服。总之，gagCEST 可能是一种有用的工具来无创评估关节软骨中的 GAG 含量，尽管异质性的不匹配需要进一步调查。显示了gagCEST MRI 与机电测量的相关性，但gagCEST MRI 与GAG 含量的相关性并不令人信服。总之，gagCEST 可能是一种有用的工具来无创评估关节软骨中的 GAG 含量，尽管异质性的不匹配需要进一步调查。

更新日期：2021-02-04

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