当前位置：
X-MOL 学术
›
NMR Biomed.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-12-22 , DOI: 10.1002/nbm.4449 Hua Huang 1 , Cun-Jing Zheng 2 , Li-Fei Wang 1 , Nazmi Che-Nordin 2 , Yì Xiáng J Wáng 2
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-12-22 , DOI: 10.1002/nbm.4449 Hua Huang 1 , Cun-Jing Zheng 2 , Li-Fei Wang 1 , Nazmi Che-Nordin 2 , Yì Xiáng J Wáng 2
Affiliation
|
The aim of this study was to establish reference values for middle‐aged subjects and to investigate the age and gender dependence of liver diffusion MRI parameters. The IVIM type of liver diffusion scan was based on a single‐shot spin‐echo–type echo‐planar sequence using a 1.5 T magnet with 16 b‐values. Diffusion‐derived vessel density (DDVD)(b0b2) or DDVD(b0b10) was the signal difference between b = 0 and b = 2 (or b = 10) s/mm2 images after removing visible vessels. IVIM analysis was performed with full fitting and segmented fitting, and with a threshold b‐value of 60 or 200 s/mm2, and fitting started from b = 2 s/mm2. Thirty‐one men (age range: 25‐71 years) and 26 men (age: 22‐69 years) had DDVD and IVIM analysis, respectively, while 37 women (age: 20‐71 years) and 36 women (age: 20‐71 years) had DDVD and IVIM analysis, respectively. DDVD results showed a significant age‐related reduction for women. IVIM results for full fitting showed excellent agreement with those for segmented fitting using a threshold b of 60 s/mm2, but this was less good for results with a threshold b of 200 s/mm2. As age increased, female subjects' Dslow measure showed a significant reduction, while their PF and Dfast measures showed a significant increase. For the age group of 40‐55 years, DDVD(b0b2), DDVD(b0b10), Dslow, PF and Dfast were 12.26 ± 3.90 au/pixel, 16.95 ± 5.45 au/pixel, 1.072 ± 0.067 (10−3 mm2/s), 0.141 ± 0.025 and 61.0 ± 14.0 (10−3 mm2/s) for men, and 13.35 ± 3.6 au/pixel, 17.20 ± 3.62 au/pixel, 1.069 ± 0.074 (10−3 mm2/s), 0.119 ± 0.014 and 57.1 ± 13.2 (10−3 mm2/s) for women, respectively. DDVD measure of this study suggest that aging is associated with a reduction in liver perfusion. There is a possibility that a lower Dslow measure is associated with artificially higher PF and Dfast measures, and that IVIM modeling of the perfusion component is constrained by the diffusion component.
中文翻译：
肝脏扩散参数的年龄和性别依赖性以及灌注分量的体素内非相干运动建模受扩散分量约束的可能性
本研究的目的是建立中年受试者的参考值，并调查肝脏弥散 MRI 参数的年龄和性别依赖性。IVIM 型肝脏弥散扫描基于单次自旋回波型回波平面序列，使用 1.5 T 磁体和 16 b 值。扩散衍生血管密度 (DDVD)(b0b2) 或 DDVD(b0b10) 是去除可见血管后b = 0 和b = 2（或b = 10）s/mm 2图像之间的信号差异。IVIM 分析采用全拟合和分段拟合，阈值b值为 60 或 200 s/mm 2，拟合从b = 2 s/mm 开始2 . 31 名男性（年龄范围：25-71 岁）和 26 名男性（年龄：22-69 岁）分别进行了 DDVD 和 IVIM 分析，而 37 名女性（年龄：20-71 岁）和 36 名女性（年龄：20 ‐71 岁）分别进行了 DDVD 和 IVIM 分析。DDVD 结果显示女性的年龄相关性显着降低。完全拟合的 IVIM 结果与使用60 s/mm 2阈值b的分段拟合结果非常一致，但对于阈值b为 200 s/mm 2 的结果不太好。随着年龄的增长，女性受试者的 D慢测量值显着降低，而她们的 PF 和 D快措施显着增加。对于 40-55 岁年龄组，DDVD(b0b2)、DDVD(b0b10)、D慢、PF 和 D快分别为 12.26 ± 3.90 au/pixel、16.95 ± 5.45 au/pixel、1.072 ± 0.067 (10 -3 mm 2 /s), 0.141 ± 0.025 和 61.0 ± 14.0 (10 -3 mm 2 /s) 男性, 13.35 ± 3.6 au/pixel, 17.20 ± 3.62 au/pixel, 1.069 ± 0.074 (10 -3 mm 2 /s) )、女性分别为0.119 ± 0.014 和 57.1 ± 13.2 (10 -3 mm 2 /s)。这项研究的 DDVD 测量表明衰老与肝脏灌注减少有关。有可能是较低的 D慢测量与人为更高的 PF 和 D快速测量相关，并且灌注分量的 IVIM 建模受扩散分量的约束。
更新日期：2021-02-04
中文翻译：
肝脏扩散参数的年龄和性别依赖性以及灌注分量的体素内非相干运动建模受扩散分量约束的可能性
本研究的目的是建立中年受试者的参考值，并调查肝脏弥散 MRI 参数的年龄和性别依赖性。IVIM 型肝脏弥散扫描基于单次自旋回波型回波平面序列，使用 1.5 T 磁体和 16 b 值。扩散衍生血管密度 (DDVD)(b0b2) 或 DDVD(b0b10) 是去除可见血管后b = 0 和b = 2（或b = 10）s/mm 2图像之间的信号差异。IVIM 分析采用全拟合和分段拟合，阈值b值为 60 或 200 s/mm 2，拟合从b = 2 s/mm 开始2 . 31 名男性（年龄范围：25-71 岁）和 26 名男性（年龄：22-69 岁）分别进行了 DDVD 和 IVIM 分析，而 37 名女性（年龄：20-71 岁）和 36 名女性（年龄：20 ‐71 岁）分别进行了 DDVD 和 IVIM 分析。DDVD 结果显示女性的年龄相关性显着降低。完全拟合的 IVIM 结果与使用60 s/mm 2阈值b的分段拟合结果非常一致，但对于阈值b为 200 s/mm 2 的结果不太好。随着年龄的增长，女性受试者的 D慢测量值显着降低，而她们的 PF 和 D快措施显着增加。对于 40-55 岁年龄组，DDVD(b0b2)、DDVD(b0b10)、D慢、PF 和 D快分别为 12.26 ± 3.90 au/pixel、16.95 ± 5.45 au/pixel、1.072 ± 0.067 (10 -3 mm 2 /s), 0.141 ± 0.025 和 61.0 ± 14.0 (10 -3 mm 2 /s) 男性, 13.35 ± 3.6 au/pixel, 17.20 ± 3.62 au/pixel, 1.069 ± 0.074 (10 -3 mm 2 /s) )、女性分别为0.119 ± 0.014 和 57.1 ± 13.2 (10 -3 mm 2 /s)。这项研究的 DDVD 测量表明衰老与肝脏灌注减少有关。有可能是较低的 D慢测量与人为更高的 PF 和 D快速测量相关，并且灌注分量的 IVIM 建模受扩散分量的约束。
京公网安备 11010802027423号