The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass‐spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.

中文翻译：

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人类松果体蛋白质组在夜间和白天和自闭症中的质谱分析

人类松果体调节多种生理过程的昼夜动态，尤其是通过分泌褪黑激素。使用基于质谱的蛋白质组学和专用分析工具，我们识别了人类松果体中的蛋白质，并系统地分析了它们在一天中的变化，并比较了对照标本和诊断为自闭症的供体之间松果体蛋白质组的这些变化。结果揭示了多种受调控的蛋白质簇，其中包括分解代谢碳水化合物过程和细胞质膜边界囊泡相关蛋白质，白天和黑夜和/或对照与自闭症松果体不同。