Engineered nanomaterials (ENMs) are intentionally designed and produced by humans to revolutionize the manufacturing sector, such as electronic goods, paints, tires, clothes, cosmetic products, and biomedicine. With the spread of these ENMs in our daily lives, scientific research have generated a huge amount of data related to their potential impacts on human and environment health. To date, these data are gathered in databases mainly focused on the (eco)toxicity and occupational exposure to ENMs. These databases are therefore not suitable to build well-informed environmental exposure scenarios covering the life cycle of ENMs. In this paper, we report the construction of one of the first centralized mesocosm database management system for environmental nanosafety (called MESOCOSM) containing experimental data collected from mesocosm experiments suited for understanding and quantifying both the environmental hazard and exposure. The database, which is publicly available through https://aliayadi.github.io/MESOCOSM-database/, contains 5200 entities covering tens of unique experiments investigating Ag, CeO₂, CuO, TiO₂-based ENMs as well as nano-enabled products. These entities are divided into different groups i.e. physicochemical properties of ENMS, environmental, exposure and hazard endpoints, and other general information about the mesocosm testing, resulting in more than forty parameters in the database. The MESOCOSM database is equipped with a powerful application, consisting of a graphical user interface (GUI), allowing users to manage and search data using complex queries without relying on programmers. MESOCOSM aims to predict and explain ENMs behavior and fate in different ecosystems as well as their potential impacts on the environment at different stages of the nanoproducts lifecycle. MESOCOSM is expected to benefit the nanosafety community by providing a continuous source of critical information and additional characterization factors for predicting ENMs interactions with the environment and their risks.

工程纳米材料 (ENM) 是人类有意设计和生产的，旨在彻底改变制造业，例如电子产品、油漆、轮胎、服装、化妆品和生物医学。随着这些 ENM 在我们日常生活中的传播，科学研究已经产生了大量与其对人类和环境健康的潜在影响相关的数据。迄今为止，这些数据收集在主要集中于 ENM 的（生态）毒性和职业暴露的数据库中。因此，这些数据库不适合构建涵盖 ENM 生命周期的消息灵通的环境暴露场景。在本文中，我们报告了第一个用于环境纳米安全的集中式中宇宙数据库管理系统（称为 MESOCOSM）的构建，其中包含从中宇宙实验收集的实验数据，适合理解和量化环境危害和暴露。该数据库可通过以下方式公开获得https://aliayadi.github.io/MESOCOSM-database/ ，包含 5200 个实体，涵盖了数十个研究Ag、CeO ₂、CuO、TiO ₂的独特实验- 基于 ENM 以及纳米产品。这些实体被分为不同的组，即 ENMS 的物理化学特性、环境、暴露和危害终点，以及有关中宇宙测试的其他一般信息，从而在数据库中产生了 40 多个参数。MESOCOSM 数据库配备了一个强大的应用程序，由图形用户界面 (GUI) 组成，允许用户使用复杂的查询来管理和搜索数据，而无需依赖程序员。MESOCOSM 旨在预测和解释 ENM 在不同生态系统中的行为和命运，以及它们在纳米产品生命周期的不同阶段对环境的潜在影响。