Immunoglobulins (Ig) are important immune molecules that possess highly diverse variable region sequences enabling antigen recognition. According to classical immune theory, B lymphocytes have been considered the only source of Ig production (B-Igs). However, accumulating evidence have suggested that Igs are also produced by many non-B cells (non-B Igs), including epithelial cells, neurons, germ cells, as well as myeloid cells of hemopoietic system. Besides acting as bona fide antibodies, Non-B Igs have alternative cellular functions, such as promotion of cell survival, adhesion and migration. More importantly, Unlike the unlimited sequence diversity of B-Igs, the non-B Igs exhibit conserved V(D)J patterns across the same lineages. To support the analysis and comparison of variable region sequences from Igs, produced by B and non-B cells, we established a database (NBIGV) constituted by a non-B Ig variable region repertoire, which includes 727,989 V_HDJ_H and VκJκ recombination sequences of non-B Igs sequenced from mouse samples. Upon database search, users can view, browse and investigate the variable region sequences of non-B Igs according to respective mice strains and tissues as well as Ig classes. Moreover, users can easily download selected sequences and/or compare sequences of interest with known non-B Ig sequences present in the database using NCBI-BLAST algorithms. Additionally, our database integrates a submission page and supplementary sample information. The NBIGV database may serve as a valuable resource for sequence analyses of Non-B Igs. NBIGV database is freely available at http://nbigv.org.

免疫球蛋白（Ig）是重要的免疫分子，具有高度可变的可变区序列，可进行抗原识别。根据经典的免疫理论，B淋巴细胞被认为是产生Ig（B-Igs）的唯一来源。但是，越来越多的证据表明，许多非B细胞（非B Ig）也产生了Ig，包括上皮细胞，神经元，生殖细胞以及造血系统的髓样细胞。除了充当真正的抗体外，Non-B Igs还具有其他细胞功能，例如促进细胞存活，粘附和迁移。更重要的是，与B-Igs的无限序列多样性不同，非B-Igs在相同谱系上显示出保守的V（D）J模式。为了支持分析和比较B细胞和非B细胞产生的Igs可变区序列，从小鼠样品测序的非B Ig的_H DJ _H和VκJκ重组序列。通过数据库搜索，用户可以根据相应的小鼠品系和组织以及Ig类型查看，浏览和研究非B Igs的可变区序列。此外，用户可以使用NCBI-BLAST算法轻松下载所选序列和/或将感兴趣的序列与数据库中存在的已知非B Ig序列进行比较。此外，我们的数据库集成了提交页面和补充样本信息。NBIGV数据库可以用作非B Ig序列分析的宝贵资源。NBIGV数据库可从http://nbigv.org免费获得。