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Chemical constituents from Psychotria arborea Hiern (Rubiaceae)
Biochemical Systematics and Ecology ( IF 1.4 ) Pub Date : 2020-12-22 , DOI: 10.1016/j.bse.2020.104212
Judith Caroline Ngo Nyobe , Willifred Dongmo Tekapi Tsopgni , Jean Pierre Longue Ekon , Ali Ben Saida , Annie Guilaine Djuidje , Anicet Biwole Bengondo , Gisele Etame Loe , Guillaume Berionni , Desire Bikele Mama , Jean Claude Ndom , Emmanuel Mpondo Mpondo

The chemical study of the stems extract of Psychotria arborea Hiern led to the isolation of thirteen compounds, including four anthraquinones: 2-methylanthracene-9,10-dione (1), 2-methoxyanthracene-9,10-dione (2), 2-hydroxy-3-methylanthracene-9,10-dione (3) and 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione (4); two diterpenes: ent-kaur-16-en-19-oic acid (5) and 15-acetoxy-ent-kaur-16-en-19-oic acid (6); two triterpenes, β-amyrin (8) and oleanolic acid (9), one flavonoid: Quercetin (7), three sterols: A mixture of stigmasterol (10) and β-sitosterol (11) and β-sitosterol-3-O-β-D-glucopyranoside (12) and one fatty acid (13). The structures of these compounds were elucidated based on NMR and HR-ESIMS analysis, further supported by comparison with previously reported spectral data. Compounds 14 and compounds 1012 were tested for their antibacterial activity against three bacteria strains Escherichia coli, Staphylococcus aureus and Salmonella enterica. All these tested compounds were found to be inactive. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail.



中文翻译:

Psychotria arborea Hiern(茜草科)的化学成分

Psychotria arborea Hiern茎提取物的化学研究导致分离出13种化合物,包括四种蒽醌:2-甲基蒽-9,10-二酮(1),2-甲氧基蒽-9,10-二酮(2),2 -羟基-3-甲基蒽-9,10-二酮(3)和3-羟基-1-甲氧基-2-甲基蒽-9,10-二酮(4);两个二萜:ent-kaur-16-en-19-oic酸(5)和15-乙酰氧基-ent-kaur-16-en-19-oic酸(6);2个三萜,β-糊精(8)和齐墩果酸(9),一种类黄酮:槲皮素(7),三种甾醇:豆甾醇的混合物(10)和β谷甾醇(11)和β谷甾醇-3- ö -β- d吡喃葡萄糖苷(12)和一种脂肪酸(13)。根据NMR和HR-ESIMS分析阐明了这些化合物的结构,并与先前报道的光谱数据进行了比较,进一步证实了这些化合物的结构。化合物1 - 4和化合物10 - 12对它们的抗菌活性进行了测试针对三种细菌菌株大肠杆菌金黄色葡萄球菌肠道沙门氏菌。发现所有这些测试的化合物均无活性。此外,详细讨论了所得化合物的化学分类学意义。

更新日期:2020-12-23
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