Despite a growth in molecular radiotherapy treatment (MRT) and an increase in interest, centres still rarely perform MRT dosimetry. The aims of this report were to assess the main reasons why centres are not performing MRT dosimetry and provide advice on the resources required to set-up such a service. A survey based in the United Kingdom was developed to establish how many centres provide an MRT dosimetry service and the main reasons why it is not commonly performed. Twenty-eight per cent of the centres who responded to the survey performed some form of dosimetry, with 88% of those centres performing internal dosimetry. The survey showed that a ‘lack of clinical evidence’, a ‘lack of guidelines’ and ‘not current UK practice’ were the largest obstacles to setting up an MRT dosimetry service. More practical considerations, such as ‘lack of software’ and ‘lack of staff training/expertise’, were considered to be of lower significance by the respondents. Following on from the survey, this report gives an overview of the current guidelines, and the evidence available demonstrating the benefits of performing MRT dosimetry. The resources required to perform such techniques are detailed with reference to guidelines, training resources and currently available software. It is hoped that the information presented in this report will allow MRT dosimetry to be performed more frequently and in more centres, both in routine clinical practice and in multicentre trials. Such trials are required to harmonise dosimetry techniques between centres, build on the current evidence base, and provide the data necessary to establish the dose–response relationship for MRT.

尽管分子放射治疗 (MRT) 的增长和兴趣的增加，中心仍然很少进行 MRT 剂量测定。本报告的目的是评估中心不进行 MRT 剂量测定的主要原因，并就建立此类服务所需的资源提供建议。在英国开展了一项调查，以确定有多少中心提供 MRT 剂量测定服务，以及它不常进行的主要原因。对调查做出回应的中心中有 28% 进行了某种形式的剂量测定，其中 88% 的中心进行了内部剂量测定。调查显示，“缺乏临床证据”、“缺乏指导方针”和“不是目前英国的做法”是建立 MRT 剂量测定服务的最大障碍。更实际的考虑，受访者认为“缺乏软件”和“缺乏员工培训/专业知识”等重要性较低。继调查之后，本报告概述了当前的指南，以及可用的证据证明执行 MRT 剂量测定的好处。参考指南、培训资源和当前可用的软件，详细说明了执行此类技术所需的资源。希望本报告中提供的信息将使 MRT 剂量测定能够在常规临床实践和多中心试验中更频繁地在更多中心进行。此类试验需要协调各中心之间的剂量测定技术，以现有证据为基础，并提供建立 MRT 剂量反应关系所需的数据。