Pretreatment to Posttreatment Hypoxia Inducible Factor-1α Ratios as a Potentially Predictive Marker for First-Line Treatment in Nonsmall Cell Lung Cancer Patients without Known Driver Mutations,Genetic Testing and Molecular Biomarkers

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Pretreatment to Posttreatment Hypoxia Inducible Factor-1α Ratios as a Potentially Predictive Marker for First-Line Treatment in Nonsmall Cell Lung Cancer Patients without Known Driver Mutations
Genetic Testing and Molecular Biomarkers ( IF 1.4 ) Pub Date : 2020-12-16 , DOI: 10.1089/gtmb.2020.0173
Mingming Hu ₁ , Tongmei Zhang ₁ , Meng Gu ₂ , Jie Li ₁ , Hongmei Zhang ₁ , Qunhui Wang ₁ , Fanbin Hu ₁ , Yuan Yang ₁ , Baolan Li ₁

Affiliation

Background: Hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) are key angiogenic regulatory factors. The aim of this study was to identify the most useful prognostic angiogenic factors in advanced nonsmall cell lung cancer (NSCLC) without known driver gene mutations.

中文翻译：

预处理至缺氧后诱导因子-1α的比率作为非小细胞肺癌无已知驱动突变的一线治疗的潜在预测指标

背景：缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）是关键的血管生成调节因子。这项研究的目的是确定没有已知驱动基因突变的晚期非小细胞肺癌（NSCLC）中最有用的预后性血管生成因子。

更新日期：2020-12-22

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