Purpose To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. Methods 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. Results In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43–53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47–53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43–53). Conclusions Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR. Data are available upon reasonable request. The dataset used for this publication was gathered from 105 diabetic patients and 38 healthy control volunteers. The dataset is composed of demographic data (gender, age) and clinical data (diabetes duration, glycated haemoglobin, best corrected visual acuity, layer retinal thickness and vessel density). Data are available upon reasonable request to José Cunha-Vaz, cunha-vaz@aibili.pt,

中文翻译：

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毛细血管闭合的扫描源 OCTA 量化预测 NPDR 的 ETDRS 严重程度分期

目的 测试用光学相干断层扫描血管造影 (OCTA) 评估的代表视网膜毛细血管闭合的单个或复合参数集是否可以根据金标准 ETDRS 分级方案预测非增殖性糖尿病视网膜病变 (NPDR) 分期。方法 105 名无视网膜病变或有不同程度视网膜病变（NPDR 至 ETDRS 53 级）的糖尿病患者使用 15×9 mm 和 3 ×3 mm 血管造影方案。获得了七张眼底照片用于 ETDRS 分期。来自年龄匹配的健康受试者的眼睛也被成像为对照。结果在没有视网膜病变或ETDRS 20和35水平的2型糖尿病患者眼中，视网膜毛细血管闭合在黄斑区，中心凹旁视网膜循环（内环）的主要改变。ETDRS 43-53 阶段的视网膜毛细血管闭合在视网膜中周占主导地位，ETDRS 43 中的血管密度平均值为 25.2±7.9（p=0.001），ETDRS 47-53 中的血管密度平均值为 23.5±3.4（p=0.001），当评估扩展时15×9 协议的区域。结合使用 SS-OCTA 的 3×3 mm 和 15×9 mm 采集协议，可以区分轻度 NPDR（ETDRS 10、20、35）的眼睛和中度至重度 NPDR（ETDRS 等级 43-53）的眼睛. 结论 SS-OCTA 量化的视网膜毛细血管闭合可以识别 NPDR 严重程度的进展。它主要位于 NPDR 初始阶段的中央凹视网膜毛细血管循环中，而在中度至重度 NPDR 中主要影响视网膜中周。可根据合理要求提供数据。本出版物使用的数据集来自 105 名糖尿病患者和 38 名健康对照志愿者。该数据集由人口统计数据（性别、年龄）和临床数据（糖尿病病程、糖化血红蛋白、最佳矫正视力、视网膜层厚度和血管密度）组成。如有合理要求，可向 José Cunha-Vaz（cunha-vaz@aibili.pt）索取数据，