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Variation in pyrethroid resistance phenotypes in Anopheles darlingi from residual malaria transmission area: warning on suspected resistance built-up in French Guiana.
bioRxiv - Zoology Pub Date : 2020-12-21 , DOI: 10.1101/2020.12.21.423491
Samuel Vezenegho , Romuald Carinci , Jean Issaly , Christophe Nguyen , Pascal Gaborit , Laetitia Ferraro , Guillaume Lacour , Emilie Mosnier , Vincent Pommier de Santi , Yanouk Epelboin , Romain Girod , Sébastien Briolant , Isabelle Dusfour

Anopheles darlingi is the major vector of malaria in South America. In French Guiana, malaria transmission occurs inland and along the rivers with a particular reemergence in the lower Oyapock area. Control against malaria vector is performed using deltamethrin indoor residual spraying and long lasting impregnated bednets. For four years, the level of resistance to pyrethroids was monitored using CDC bottle tests in An. darlingi populations. Resistance built-up was suspected in a mosquito population in malaria endemic area but did not sustained, supposably due to the reintroduction of susceptible alleles. No mutation on the insecticide target genes was found, metabolic resistance is then suspected.

中文翻译:

来自残留疟疾传播地区的达氏按蚊中拟除虫菊酯抗药性表型的变化:关于法属圭亚那可疑抗药性的警告。

达林按蚊是南美地区疟疾的主要传播媒介。在法属圭亚那,疟疾通过内陆和沿河传播,在奥亚波克下游地区尤为明显。使用溴氰菊酯室内残留喷雾剂和长期浸渍的蚊帐来控制疟疾。四年来,使用An中的CDC瓶测试监测了对拟除虫菊酯的抗药性水平达令吉人口。怀疑在疟疾流行地区的蚊子种群中产生了抗药性,但这种抗药性没有持续,这可能是由于易感等位基因的重新引入。没有发现杀虫剂目标基因的突变,因此怀疑有代谢抗性。
更新日期:2020-12-22
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