Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors,Biomacromolecules

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Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-21 , DOI: 10.1021/acs.biomac.0c01321
Jakub W Trzciński ₁ , Lucía Morillas-Becerril ₁ , Sara Scarpa _{2,

3} , Marco Tannorella ₁ , Francesco Muraca ₁ , Federico Rastrelli ₁ , Chiara Castellani ₄ , Marny Fedrigo ₄ , Annalisa Angelini ₄ , Regina Tavano _{2,

3} , Emanuele Papini _{2,

3} , Fabrizio Mancin ₁

Affiliation

Herein we present an innovative approach to produce biocompatible, degradable, and stealth polymeric nanoparticles based on poly(lipoic acid), stabilized by a PEG-ended surfactant. Taking advantage of the well-known thiol-induced polymerization of lipoic acid, a universal and nontoxic nanovector consisted of a solid cross-linked polymeric matrix of lipoic acid monomers was prepared and loaded with active species with a one-step protocol. The biological studies demonstrated a high stability in biological media, the virtual absence of “protein” corona in biological fluids, the absence of acute toxicity in vitro and in vivo, complete clearance from the organism, and a relevant preference for short-term accumulation in the heart. All these features make these nanoparticles candidates as a promising tool for nanomedicine.

中文翻译：

基于聚硫辛酸的纳米粒子作为自组织，生物相容和无电晕的纳米载体

本文中，我们提出了一种创新的方法来生产基于聚（硫辛酸）的生物相容性，可降解和隐形聚合物纳米颗粒，并通过PEG端基表面活性剂对其进行稳定化处理。利用众所周知的硫醇诱导的硫辛酸聚合，制备了由硫辛酸单体的固态交联聚合物基质组成的通用且无毒的纳米载体，并通过一步操作步骤将其负载到活性物质上。生物学研究表明，在生物介质中具有很高的稳定性，在生物流体中几乎不存在“蛋白”电晕，在体外和体内均不存在急性毒性，可以完全清除生物体，并且优先选择在体内短期积累。心。所有这些特征使这些纳米颗粒成为纳米医学的有前途的工具。

更新日期：2021-02-08

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