Abstract

The present study was focused on synthesis of silver nanoparticles using Russelia equisitiformis plant (RelAgNps) and flower extracts (RefAgNps). Thus, the nanoparticles synthesis was confirmed using UV spectrometry and the FT-IR results showed the presence of similar compounds in the plant extract and FESEM-EDAX reveals the size, shape, and elemental composition of synthesized nanoparticles. The antioxidant activity of the RefAgNps from flower extract and RelAgNps from leaf extract was observed at the concentration of 25 μg/mL but the percentage of antioxidant activity of flower extract was comparatively higher than the leaf extract. This plant is also known to have antidiabetic activity and thus leaf extract and flower extract mediated nanoparticles is also known to have alpha amylase inhibition activity at the concentration of 12.5 and 100 μg/mL, respectively. Molecular docking of the plant compounds10-O-cinnamoyl sinuatol and rehmaglutin B were docked with alpha amylase enzyme proves the same with the binding energy of −9.1 kcal/mol. Thus, to the best of our knowledge this is the first-time nanoparticles have been synthesized using R. equisitiformis flower and leaf extract and observed to have potent antioxidant and antidiabetic activity.

摘要

本研究的重点是使用Russelia equisitiformis合成银纳米粒子植物 (RelAgNps) 和花卉提取物 (RefAgNps)。因此，纳米粒子的合成通过紫外光谱法得到证实，FT-IR 结果表明植物提取物中存在类似的化合物，FESEM-EDAX 揭示了合成纳米粒子的大小、形状和元素组成。在25 μg/mL的浓度下观察到来自花提取物的RefAgNps和来自叶提取物的RelAgNps的抗氧化活性，但花提取物的抗氧化活性百分比相对高于叶提取物。这种植物还已知具有抗糖尿病活性，因此叶提取物和花提取物介导的纳米颗粒也分别在 12.5 和 100 μg/mL 的浓度下具有 α 淀粉酶抑制活性。植物化合物10-O-肉桂酰sinuatol和rehmaglutin B与α淀粉酶的分子对接证明相同，结合能为-9.1 kcal/mol。因此，据我们所知，这是第一次使用合成纳米粒子R. equisitiformis花和叶提取物，并观察到具有有效的抗氧化和抗糖尿病活性。