Abstract

This study examined the association between coffee consumption and all-cause mortality in patients with a prior acute myocardial infarction or unstable angina. Data were from the prospective study ERICO, totalising 928 patients with Acute Coronary Syndrome (ACS). During 4 years’ follow-up, a total of 111 deaths occurred. Moderate coffee consumption (1–2 and 2–3 cups/day) was inversely associated with total mortality (HR 0.13, 95% CI: 0.06–0.29 and 0.22, 95% CI: 0.13–0.39, respectively). For patients with higher coffee consumption (>3 cups/day), there was a positive association with mortality (HR 2.12, 95% CI: 1.06–4.24). After stratification by smoking status, the analysis revealed lower risk of mortality in never and former smokers, drinking 1–2 and 2–3 cups/day. Among current smokers there was a positive association between >3 cups/day and mortality. The moderate consumption of coffee was associated with lower risk of all-cause mortality in patients with a prior ACS, particularly in non-smokers.

摘要

这项研究检查了咖啡消费量与既往急性心肌梗死或不稳定心绞痛患者全因死亡率之间的关联。数据来自前瞻性研究 ERICO，共有 928 名急性冠状动脉综合征 (ACS) 患者。在 4 年的随访中，共有 111 人死亡。适度饮用咖啡（1-2 杯和 2-3 杯/天）与总死亡率呈负相关（HR 0.13，95% CI：0.06-0.29 和 0.22，95% CI：0.13-0.39，分别）。对于咖啡摄入量较高（> 3 杯/天）的患者，与死亡率呈正相关（HR 2.12，95% CI：1.06–4.24）。按吸烟状况分层后，分析显示从不吸烟者和以前吸烟者的死亡风险较低，每天饮酒 1-2 杯和 2-3 杯。在当前吸烟者中， > 3 杯/天和死亡率。适度饮用咖啡与既往 ACS 患者的全因死亡率降低相关，尤其是非吸烟者。