Abstract

Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (3), in addition to three known compounds, 3′-O-methylorobol (4), robusflavone B (5), and apigenin (6). The structural elucidation of these compounds was achieved by analyses of their spectroscopic data (HR-ESI-MS, 1 D- and 2 D-NMR) and acidic hydrolysis. The U. crinita extracts and compounds 1–6 exhibited weak or no cytotoxic activity against KB, HepG2, Lu and MCF7 cell lines.

摘要

重新研究Uraria crinita的甲醇提取物，得到新的 3-羟基异黄烷酮、3,5,7,2',4'-五羟基异黄烷酮 ( 1 )、两种新的单芳基葡糖苷、3,4-二甲氧基苯基 1- O- (6'- O-乙酰基）-β -D-吡喃葡萄糖苷（2）和3,4,5-三甲氧基苯基1- O-（6' - O-乙酰基）-β -D-吡喃葡萄糖苷（3），除了三种已知化合物， 3'- O -methylorobol ( 4 )、robusflavone B ( 5 ) 和芹菜素 ( 6）。通过分析它们的光谱数据（HR-ESI-MS、1 D-和 2 D-NMR）和酸性水解来实现这些化合物的结构解析。U. crinita提取物和化合物1-6对KB 、 HepG2 、 Lu 和 MCF7 细胞系表现出微弱或没有细胞毒活性。