Cross-Coupling of Allenamides and C-Based Nucleophiles by Pd-Catalyzed Allylic Alkylation,Israel Journal of Chemistry

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Cross-Coupling of Allenamides and C-Based Nucleophiles by Pd-Catalyzed Allylic Alkylation
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2020-12-22 , DOI: 10.1002/ijch.202000096
Joshua D. Sieber ₁ , Raphael K. Klake ₁ , Toolika Agrawal ₁ , Dang Binh Ho ₁ , Samantha L. Gargaro ₁ , Stephen Collins ₁ , Mytia D. Edwards ₁

Affiliation

Pd-catalyzed allylic alkylation of C-based nucleophiles using both chiral and achiral allenamides is described. High yields were obtained to provide synthetically valuable (E)-enamide products in high E : Z-selectivity while generating a quaternary carbon atom. Some potential stereocontrolled applications of the resultant (E)-enamide functionality are described.

中文翻译：

通过 Pd 催化的烯丙基烷基化交叉偶联 Allenamides 和 C 基亲核试剂

描述了使用手性和非手性丙二烯酰胺对C基亲核试剂进行Pd 催化的烯丙基烷基化。获得高产率以提供具有高E:Z选择性的具有合成价值的 ( E )-烯酰胺产品，同时生成季碳原子。描述了所得 ( E )-烯酰胺官能团的一些潜在立体控制应用。

更新日期：2020-12-22

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