Decontamination of SARS‐CoV‐2 Contaminated N95 Filtering Facepiece Respirators (FFRs) with Moist Heat Generated by a Multicooker,Letters in Applied Microbiology

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Decontamination of SARS‐CoV‐2 Contaminated N95 Filtering Facepiece Respirators (FFRs) with Moist Heat Generated by a Multicooker
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-12-31 , DOI: 10.1111/lam.13443
Y.W. Choi ₁ , A.W. Richardson ₁ , M. Sunderman ₁ , M.J. Mladineo ₁ , P.H. Keyes ₁ , K.C. Hofacre ₁ , J.K. Middleton ₁

Affiliation

Decontamination of N95 filtering facepiece respirators (FFRs) is a crisis capacity strategy allowed when there are known shortages of FFRs. The application of moist heat is one decontamination method that has shown promise and is the approach approved in the Steris Steam Emergency Use Authorization (EUA). This effort examines the use of multicookers to apply moist heat, as they are available in retail stores and more affordable than methods requiring more sophisticated equipment. Four of five multicooker models examined met the acceptance criteria for the test and one model was selected for inactivation testing. Tests were performed on four different FFR models with SARS-CoV-2 suspended in culture media, simulated saliva, or simulated lung fluid. Moist heat treatment reduced recoverable titers of SARS-CoV-2 virus to levels below the limit of detection in all tests. Furthermore, these four FFR models showed no loss in collection efficiency, inhalation resistance, or visual damage after up to 10 decontamination cycles. Two (2) FFR models showed a slight change in strap elasticity (<9%). These data show that moist heat treatment using a multicooker is a viable option for FFR decontamination in a crisis capacity strategy.

中文翻译：

用多功能炊具产生的湿热净化受 SARS-CoV-2 污染的 N95 过滤式面罩呼吸器 (FFR)

N95 过滤式面罩呼吸器 (FFR) 的净化是在已知 FFR 短缺时允许的危机容量策略。湿热应用是一种已显示出前景的去污方法，并且是 Steris Steam 紧急使用授权 (EUA) 批准的方法。这项工作研究了使用多功能炊具施加湿热，因为它们在零售店有售，而且比需要更复杂设备的方法更实惠。所检查的五个多功能炊具模型中有四个符合测试的验收标准，并且选择了一个模型进行灭活测试。在四种不同的 FFR 模型上进行了测试，其中 SARS-CoV-2 悬浮在培养基、模拟唾液或模拟肺液中。在所有测试中，湿热处理将 SARS-CoV-2 病毒的可恢复滴度降低到低于检测限的水平。此外，在多达 10 次净化循环后，这四种 FFR 模型均未显示收集效率、吸入阻力或视觉损伤方面的损失。两 (2) 个 FFR 模型显示带弹性略有变化 (<9%)。这些数据表明，在危机容量战略中，使用多功能锅进行湿热处理是 FFR 净化的可行选择。

更新日期：2020-12-31

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