Poly‐L‐lysine‐coated, highly microporous silicon nanoparticles are herein characterized and successfully used as longer‐lived luminescent probes for in vivo time‐gated imaging using Hydra vulgaris as model organism. The uptake in living polyp is promoted by the positive surface charge of the nanocomposite. The outcomes show that time gating allows to get rid of nonspecific tissue autofluorescence and leads to a contrast enhancement by a factor > 1 order of magnitude.

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封面

本文描述了涂有聚L-赖氨酸的高微孔硅纳米颗粒，并成功地将其用作长寿命的发光探针，用于使用寻常蛇蝎作为模型生物进行体内时间门控​​成像。纳米复合材料的正表面电荷促进了活息肉的摄取。结果表明，时间门控可以消除非特异性组织自身荧光，并导致对比度增强> 1个数量级。