Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients,Acta Physiologica

当前位置： X-MOL 学术 › Acta Physiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-12-22 , DOI: 10.1111/apha.13610
J Thomas Hannich ₁ , Ursula Loizides-Mangold _{2,

3,

4,

5} , Flore Sinturel _{2,

3,

4,

5} , Takeshi Harayama ₁ , Bart Vandereycken ₆ , Camille Saini ₇ , Pauline Gosselin _{2,

3,

4,

5,

7} , Marie-Claude Brulhart-Meynet ₂ , Maud Robert ₈ , Stephanie Chanon ₉ , Christine Durand ₉ , Jonathan Paz Montoya ₁₀ , Fabrice P A David ₁₁ , Idris Guessous ₇ , Zoltan Pataky ₁₂ , Alain Golay ₁₂ , François R Jornayvaz _{2,

4} , Jacques Philippe _{2,

4} , Emmanouil T Dermitzakis _{4,

5,

13} , Steven A Brown ₁₄ , Etienne Lefai ₁₅ , Howard Riezman ₁ , Charna Dibner _{2,

3,

4,

5}

Affiliation

Department of Biochemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland.
Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Department of Mathematics, University of Geneva, Geneva, Switzerland.
Department and Division of Primary Care Medicine, University Hospital of Geneva, Geneva, Switzerland.
Department of Digestive and Bariatric Surgery, Edouard Herriot University Hospital, University, Lyon, France.
CarMeN Laboratory, INSERM U1060, INRA 1397, University Lyon 1, Oullins, France.
Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Gene Expression Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, WHO Collaborating Centre, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
INRA, Unité de Nutrition Humaine, Université Clermont Auvergne, Paris, France.

The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health challenge. Chronically altered lipids induced by obesity further promote the development of T2D, and the accumulation of toxic lipid metabolites in serum and peripheral organs may contribute to the diabetic phenotype.

中文翻译：