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L‐alanine supplementation improves blood glucose level and biochemical indices in alloxan‐induced diabetic rats
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-12-21 , DOI: 10.1111/jfbc.13590 Shamsudeen Umar Dandare 1 , Ifeanyi Jude Ezeonwumelu 2 , Tijjani Salihu Shinkafi 1 , Umar Faruk Magaji 3 , Abdulbaki Alfa-Ibrahim Adio 1 , Kasimu Ahmad 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-12-21 , DOI: 10.1111/jfbc.13590 Shamsudeen Umar Dandare 1 , Ifeanyi Jude Ezeonwumelu 2 , Tijjani Salihu Shinkafi 1 , Umar Faruk Magaji 3 , Abdulbaki Alfa-Ibrahim Adio 1 , Kasimu Ahmad 1
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Diabetes is a metabolic disorder whose complications are among the leading cause of death. In this study, the antidiabetic effect of L‐alanine was tested in alloxan‐induced diabetic rats. Thirty‐five male albino Wistar rats were divided into five groups viz; Group I and II: nondiabetic and diabetic controls respectively; Group III and IV: 150 and 300 mg/kg b.w. L‐alanine treated, respectively; Group V: glibenclamide (0.5 mg/kg b.w.) treated. Weight and blood glucose were monitored during the study, while liver and kidney functions, lipid profile, and antioxidant markers were examined at the end of the study. The outcomes indicate that 300 mg/kg L‐alanine resulted to a significant decrease (p < .05) in weight and blood glucose. L‐alanine restored tissue antioxidants, kidney, and liver functions by improving important parameters. Histopathological studies showed the potential of L‐alanine in regeneration of the islets of Langerhans. These findings suggest that L‐alanine has an alleviating effect on alloxan‐induced diabetes.
中文翻译：
补充L-丙氨酸可改善四氧嘧啶致糖尿病大鼠的血糖水平和生化指标
糖尿病是一种代谢紊乱，其并发症是导致死亡的主要原因。在这项研究中，在四氧嘧啶诱导的糖尿病大鼠中测试了L-丙氨酸的抗糖尿病作用。将35只雄性白化病Wistar大鼠分为5组，分别为：第一组和第二组：分别为非糖尿病和糖尿病对照组；第三和第四组：分别以150和300 mg / kg bw的L-丙氨酸处理；第五组：格列苯脲（0.5 mg / kg体重）处理。在研究过程中监测体重和血糖，在研究结束时检查肝和肾功能，脂质分布和抗氧化剂标志物。结果表明，300 mg / kg的L-丙氨酸显着降低（p <0.05）。L-丙氨酸可通过改善重要参数来恢复组织抗氧化剂，肾脏和肝脏的功能。组织病理学研究表明，L-丙氨酸在朗格汉斯胰岛再生中具有潜力。这些发现表明，L-丙氨酸对四氧嘧啶引起的糖尿病具有缓解作用。
更新日期：2021-01-19
中文翻译：
补充L-丙氨酸可改善四氧嘧啶致糖尿病大鼠的血糖水平和生化指标
糖尿病是一种代谢紊乱，其并发症是导致死亡的主要原因。在这项研究中，在四氧嘧啶诱导的糖尿病大鼠中测试了L-丙氨酸的抗糖尿病作用。将35只雄性白化病Wistar大鼠分为5组，分别为：第一组和第二组：分别为非糖尿病和糖尿病对照组；第三和第四组：分别以150和300 mg / kg bw的L-丙氨酸处理；第五组：格列苯脲（0.5 mg / kg体重）处理。在研究过程中监测体重和血糖，在研究结束时检查肝和肾功能，脂质分布和抗氧化剂标志物。结果表明，300 mg / kg的L-丙氨酸显着降低（p <0.05）。L-丙氨酸可通过改善重要参数来恢复组织抗氧化剂，肾脏和肝脏的功能。组织病理学研究表明，L-丙氨酸在朗格汉斯胰岛再生中具有潜力。这些发现表明，L-丙氨酸对四氧嘧啶引起的糖尿病具有缓解作用。
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