Optochemical Control of DNA‐Switching Circuits for Logic and Probabilistic Computation,Angewandte Chemie International Edition

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Optochemical Control of DNA‐Switching Circuits for Logic and Probabilistic Computation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-12-22 , DOI: 10.1002/anie.202013883
Xiewei Xiong ₁ , Mingshu Xiao ₁ , Wei Lai ₁ , Li Li ₁ , Chunhai Fan ₂ , Hao Pei ₁

Affiliation

Precise control of DNA‐circuit functions facilitates the construction of complex DNA networks to perform sophisticated functions. Inspired by optochemical genetics with high precision for controlling and studying neural networks by photoregulation of membrane receptors, we herein report optochemically controlled DNA switching circuits for regulating computation functions. The DNA‐switching circuits involve a CG–C⁺ triplex‐based DNA switch that undergoes structural transition from triplex to duplex states after exposure to UV irradiation due to proton transfer, showing optochemical control. We demonstrate that the DNA‐switching circuits enable the regulation of computation functions by optochemical control of the state of the DNA switch, including multiple logic computations and probabilistic computation. We hope this work will broaden DNA‐circuit functions and facilitate the construction of complex DNA networks.

中文翻译：

DNA交换电路的光化学控制，用于逻辑和概率计算

对DNA电路功能的精确控制有助于构建复杂的DNA网络以执行复杂的功能。受光化学遗传学的启发，该技术以高精度通过膜受体的光调节来控制和研究神经网络，在此我们报道了光化学控制的DNA开关电路，用于调节计算功能。DNA交换电路涉及CG–C ⁺基于三重态的DNA开关，由于质子转移而暴露于紫外线照射后，经历了从三重态到双态的结构转变，显示出光化学控制。我们证明了DNA交换电路可以通过光化学控制DNA开关的状态来实现计算功能的调节，包括多重逻辑计算和概率计算。我们希望这项工作将拓宽DNA电路功能并促进复杂DNA网络的构建。

更新日期：2021-02-08

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