Antipsychotic drugs are well established to alter serum prolactin levels, often resulting in adverse effects including amenorrhea, galactorrhea, osteoporosis, and loss of libido. There is growing preclinical evidence that prolactin-elevating drugs can instigate the progression of precancerous lesions to breast cancer and that genes activated by prolactin are associated with the development and proliferation of breast cancer. Current guides advise a cautious approach (weighing risks and benefits) to the administration of prolactin-elevating antipsychotic drugs in women with a previously detected breast cancer. Aripiprazole is known to be a prolactin-sparing antipsychotic; however, data regarding its effects on prolactin and estrogens in postmenopausal women are lacking.

中文翻译：

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接受阿立哌唑增强治疗抑郁症的绝经后妇女的催乳素和雌激素水平。

抗精神病药物可以改变血清催乳素水平，通常会导致包括闭经、溢乳、骨质疏松症和性欲减退在内的不良反应。越来越多的临床前证据表明，提高催乳素的药物可以促使癌前病变向乳腺癌发展，催乳素激活的基因与乳腺癌的发展和增殖有关。目前的指南建议对先前检测到的乳腺癌女性使用提高催乳素的抗精神病药物采取谨慎的方法（权衡风险和收益）。众所周知，阿立哌唑是一种不含催乳素的抗精神病药。然而，缺乏关于其对绝经后妇女催乳素和雌激素影响的数据。