Biosynthesis of alkyne-containing natural products,RSC Chemical Biology

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Biosynthesis of alkyne-containing natural products
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-12-21 , DOI: 10.1039/d0cb00190b
Xinyang Li ₁ , Jian-Ming Lv ₂ , Dan Hu ₂ , Ikuro Abe _{1,

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Affiliation

Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce de novo biosynthetic strategies for alkyne-tagged compound production.

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