Electrochemically promoted C-3 amination of 2H-indazoles,Organic Chemistry Frontiers

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Electrochemically promoted C-3 amination of 2H-indazoles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-12-11 , DOI: 10.1039/d0qo01088j
Mingli Sun _{1,

2,

3,

4,

5} , Yuhui Zhou _{1,

2,

3,

4} , Laiqiang Li _{5,

6,

7,

8} , Lei Wang _{1,

2,

3,

4,

5} , Yongmin Ma _{1,

2,

3,

4} , Pinhua Li _{5,

6,

7,

8}

Affiliation

This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.

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