Single-cell Sequencing in the Field of Stem Cells,Current Genomics

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Single-cell Sequencing in the Field of Stem Cells
Current Genomics ( IF 1.8 ) Pub Date : 2020-12-21 , DOI: 10.2174/1389202921999200624154445
Tian Chen ₁ , Jiawei Li ₁ , Yichen Jia ₁ , Jiyan Wang ₂ , Ruirui Sang ₃ , Yi Zhang ₄ , Ruiming Rong ₁

Affiliation

Variation and heterogeneity between cells are the basic characteristics of stem cells. Traditional sequencing analysis methods often cover up this difference. Single-cell sequencing technology refers to the technology of high-throughput sequencing analysis of genomes at the single-cell level. It can effectively analyze cell heterogeneity and identify a small number of cell populations. With the continuous progress of cell sorting, nucleic acid extraction and other technologies, single-cell sequencing technology has also made great progress. Encouraging new discoveries have been made in stem cell research, including pluripotent stem cells, tissue-specific stem cells and cancer stem cells. In this review, we discuss the latest progress and future prospects of single-cell sequencing technology in the field of stem cells.

中文翻译：

干细胞领域的单细胞测序

细胞间的变异和异质性是干细胞的基本特征。传统的测序分析方法往往掩盖了这种差异。单细胞测序技术是指在单细胞水平上对基因组进行高通量测序分析的技术。它可以有效地分析细胞异质性并识别少量细胞群。随着细胞分选、核酸提取等技术的不断进步，单细胞测序技术也取得了长足的进步。干细胞研究取得了令人鼓舞的新发现，包括多能干细胞、组织特异性干细胞和癌症干细胞。在这篇综述中，我们讨论了单细胞测序技术在干细胞领域的最新进展和未来前景。

更新日期：2020-12-21

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