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Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha
Natural Product Communications ( IF 1.5 ) Pub Date : 2020-12-16 , DOI: 10.1177/1934578x20977622
Virginie Flaure Tsague Tankeu 1, 2 , Denis Kehdinga Sema 1, 2, 3 , Jean-Bosco Jouda 4 , Simplice Joel N. Tatsimo 2 , Patrick Akono Ntonga 5 , Jean Duplex Wansi 6 , Simeon Kouam Fogue 7 , Benoît Loura 8 , Yoshihito Shiono 9 , Norbert Sewald 3 , Alain Meli Lannang 2, 3, 4
Affiliation  

One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison with literature data. All compounds were assayed for their antimicrobial and cytotoxic properties. Only compound 2 showed antimicrobial activities against Bacillus subtilis DSMZ 704, Pseudomonas agarici DSMZ 11810, and Micrococcus luteus DSMZ 1605 with minimum inhibitory concentration values of 9.3, 15.5, and 16.9 µg/mL respectively. None of the isolated compounds showed a significant cytotoxic property.



中文翻译:

Heptacyclosordarianone,一种来自Sordaria sp。的新型聚酮化合物,一种来自藤黄的内生真菌

Sordaria sp。的提取物中分离到一种新的聚酮衍生物七环七氢蒽酮(1)和两种已知化合物七环七氢萘醌(2)和香酚(3)。AM-71,一种居住在藤黄中的内生真菌。这些化合物的结构基于核磁共振光谱和高分辨率质谱分析以及与文献数据的比较得到阐明。测定所有化合物的抗微生物和细胞毒性特性。仅化合物2枯草芽孢杆菌DSMZ 704 ,琼脂假单胞菌DSMZ 11810和黄褐微球菌DSMZ 1605的最小抑菌浓度分别为9.3、15.5和16.9 µg / mL。分离的化合物均未显示出明显的细胞毒性。

更新日期:2020-12-21
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