In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an “extensive societal dialogue” was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.

中文翻译：

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可遗传的人类基因组编辑：公众参与势在必行

在许多人看来，可遗传的人类基因组编辑 (HHGE) 具有消除世界上致命遗传疾病的治疗潜力。希波克拉底义务，如果有的话，HHGE 被广泛视为一种维持生命的命题。然而，在作者的集体看来，关于实施 HHGE 的国家通过/不通过决定不得在没有彻底公众参与的情况下进行。人类生殖系基因组编辑临床应用国际委员会最近发出了类似的呼吁，要求进行“广泛的社会对话”。在这篇通讯中，作者阐述了支撑舆论形成、修改和评估的基本原则。正是在这种背景下，社会决定保证或禁止 HHGE 的临床行为无疑会发生。