Modular Assembly of Drug and Monodisperse SPIONs for Superior Magnetic and T2-Imaging Performance,Bioconjugate Chemistry

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Modular Assembly of Drug and Monodisperse SPIONs for Superior Magnetic and T2-Imaging Performance
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-12-21 , DOI: 10.1021/acs.bioconjchem.0c00597
Huan Shen ₁ , Ergang Liu ₂ , Shijie Xu ₃ , Weiwei Tang ₁ , Jie Sun ₁ , Zhenguo Gao ₁ , Junbo Gong ₁

Affiliation

Development of superparamagnetic iron oxide nanoparticles (SPIONs) based theranostics has suffered due to its self-contradictory requirements on water dispersity and drug loadings. Generally well-dispersed SPIONs have excellent MRI performance but are insensitive to magnetism mediated delivery. Besides, loading hydrophobic drugs also hampers the stability of SPIONs which is critical for their biomedical applications. Considering these aspects, we employed curcumin as a cross-linking agent to facilitate the modular assembly of drug and monodisperse SPIONs (Cur/ALN-β-CD-SPIONs). Interestingly, the saturation magnetization of Cur/ALN-β-CD-SPIONs is higher than that of ALN-β-CD-SPIONs, and the value of r₂ indicating the negative contrast ability increases to 389.96 mM^–1 s^–1. Furthermore, the Cur/ALN-β-CD-SPIONs are very stable in PBS buffer over 3 weeks. The mice treated with Cur/ALN-β-CD-SPIONs by tail vein injection displayed a better tumor inhibition effect than that of free curcumin. This study provides a simple method for modular assembly of drug and monodisperse SPIONs, which is crucial to the design of SPIONs with superior T₂-imaging performance and drug delivery.

中文翻译：

药物和单分散 SPION 的模块化组装，以实现卓越的磁性和 T2 成像性能

由于其对水分散性和载药量的自相矛盾的要求，基于超顺磁性氧化铁纳米粒子 (SPION) 的治疗诊断学的发展受到了影响。通常，分散良好的 SPION 具有出色的 MRI 性能，但对磁介导的传递不敏感。此外，加载疏水性药物也阻碍了 SPIONs 的稳定性，这对其生物医学应用至关重要。考虑到这些方面，我们采用姜黄素作为交联剂来促进药物和单分散 SPIONs (Cur/ALN-β-CD-SPIONs) 的模块化组装。有趣的是，Cur/ALN-β-CD-SPIONs 的饱和磁化强度高于 ALN-β-CD-SPIONs，并且r ₂的值表明负对比能力增加到 389.96 mM ^–1 s^–1 . 此外，Cur/ALN-β-CD-SPIONs 在 PBS 缓冲液中在 3 周内非常稳定。尾静脉注射Cur/ALN-β-CD-SPIONs的小鼠比游离姜黄素具有更好的抑瘤作用。这项研究为药物和单分散 SPION 的模块化组装提供了一种简单的方法，这对于设计具有卓越 T ₂成像性能和药物递送的 SPION 至关重要。

更新日期：2021-01-20

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