Abstract

Aim

To evaluate the short-term effect of 0.15% sodium hyaluronate (SH), 0.20% SH, and Trehalose + 0.15% SH on anterior corneal aberrations in dry eye patients.

Methods

76 eyes of 76 dry eye patients were divided into three groups. Non-preserved 1.5 mg/mL SH was administered in group 1, non-preserved 2.0 mg/mL SH was administered in group 2, and non-preserved trehalose 30 mg/mL and 1.5 mg/mL SH was administered in group 3. Aberrometry measurements were performed before and 10 min after application of the artificial tear drop. Using the Pentacam Scheimpflug imaging system, total root mean square (RMS), lower-order aberration (LOA), higher-order aberrations (HOAs), spherical aberration (SA), trefoil, and coma aberrations were investigated.

Results

In each group; the RMS of total, LOA, HOAs, and spherical aberration were significantly decreased after the artificial drop instillation, compared with those of them at baseline; and in groups 1 and 2, vertical trefoil term was also significantly increased, compared with those of them at baseline. According to intergroup analyzes, there was no significant outcome.

Conclusions

It was observed that three artificial tears reduced the anterior corneal aberrations, in a 10-min period. The short-term effect of three artificial tears on the anterior corneal aberration was similar.

中文翻译：

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海藻糖和不同剂量透明质酸钠对干眼症患者角膜前部像差的短期影响

摘要

目标

评估 0.15% 透明质酸钠 (SH)、0.20% SH 和海藻糖 + 0.15% SH 对干眼症患者角膜前部像差的短期影响。

方法

将76名干眼症患者的76只眼分为三组。第 1 组给予非防腐剂 1.5 mg/mL SH，第 2 组给予非防腐剂 2.0 mg/mL SH，第 3 组给予非防腐剂海藻糖 30 mg/mL 和 1.5 mg/mL SH。在使用人工泪滴之前和之后 10 分钟进行测量。使用 Pentacam Scheimpflug 成像系统，研究了总均方根 (RMS)、低阶像差 (LOA)、高阶像差 (HOA)、球面像差 (SA)、三叶形和彗形像差。

结果

在每个组中；人工滴注后总均方根值、LOA、HOA和球面像差均较基线时显着降低；在第 1 组和第 2 组中，与基线相比，垂直三叶期也显着增加。根据组间分析，没有显着结果。

结论

据观察，三个人工泪液在 10 分钟内减少了前角膜像差。三种人工泪液对角膜前像差的短期影响相似。