Abstract

Objective

The purpose of the study was to investigate the association between andropause symptoms and sickness absence in Japanese male workers over 2 years.

Methods

A baseline survey asking about andropause symptoms, along with blood sampling for testosterone level, was conducted in June 2009. A total of 418 men (mean age = 52.4 years, SD = 8.6) participated and were followed through 2011. Hazard ratios (HRs) and 95% confidence intervals (CIs) for sickness absence were calculated using Cox proportional hazard models.

Results

During the follow-up period, 31 of 35 participants who took sickness absences had physical illnesses. A higher andropause symptom score was associated with an increased risk of sickness absence. Testosterone deficiency (<350 ng/dL) was not associated with sickness absence. Among the subscales of andropause symptoms, the somatic symptom score was positively associated with sickness absence, whereas testosterone deficiency combined with high sexual symptoms was not associated with sickness absence. Results were similar when limited to sickness absence because of physical illness. No significant interaction between andropause symptoms and testosterone deficiency was found.

Conclusions

Non-specific andropause symptoms unrelated to testosterone deficiency were positively associated with sickness absence.

中文翻译：

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日本男性工人的更年期症状和疾病缺席：一项前瞻性研究

摘要

客观的

该研究的目的是调查 2 年多来日本男性工人的男性更年期症状与疾病缺勤之间的关系。

方法

2009 年 6 月进行了一项关于男性更年期症状的基线调查以及对睾酮水平的血液采样。共有 418 名男性（平均年龄 = 52.4 岁，SD = 8.6）参与并跟踪到 2011 年。风险比 (HRs)使用 Cox 比例风险模型计算疾病缺勤的 95% 置信区间 (CI)。

结果

在随访期间，35 名因病缺勤的参与者中有 31 人患有身体疾病。较高的男性更年期症状评分与病假风险增加有关。睾酮缺乏 (<350 ng/dL) 与病假无关。在男性更年期症状的分量表中，躯体症状评分与疾病缺席呈正相关，而睾酮缺乏合并高性症状与疾病缺席无关。当仅限于因身体疾病而缺勤时，结果相似。没有发现男性更年期症状和睾酮缺乏之间的显着相互作用。

结论

与睾酮缺乏无关的非特异性男性更年期症状与疾病缺席呈正相关。