Abstract

A new 4-hydroxy-α-pyrone, namely capsulactone (1), was isolated from an endophytic fungus Penicillium capsulatum XL027 obtained from the leaves of Panax notoginseng. The structure and absolute configuration of 1 were elucidated through a combination of spectroscopic data and computed methods, as well as by comparison with literature data. Compound 1 exhibited weak activity against methicinllin-resistant Staphylococcus aureus with an MIC value of 100 μg/ml.

中文翻译：

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Capsulactone：来自内生真菌Penicillium capsulatum的新型4-羟基-α-吡喃酮衍生物及其抗菌活性

摘要

一种新的 4-羟基-α-吡喃酮，即胶囊内酯 ( 1)，是从从三七叶中获得的内生真菌Penicillium capsulatum XL027 中分离出来的。通过光谱数据和计算方法相结合，以及与文献数据的比较，阐明了1的结构和绝对构型。化合物1对耐甲氧西林金黄色葡萄球菌的活性较弱，MIC值为100 μg/ml。