当前位置: X-MOL 学术Expert Rev. Anti Infect. Ther. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Calycosin: a Review of its Pharmacological Effects and Application Prospects
Expert Review of Anti-infective Therapy ( IF 4.2 ) Pub Date : 2020-12-21 , DOI: 10.1080/14787210.2021.1863145
Mao Deng 1 , Huijuan Chen 1 , Jiaying Long 1 , Jiawen Song 1 , Long Xie 1 , Xiaofang Li 1
Affiliation  

ABSTRACT

Introduction: Calycosin (CA), a typical phytoestrogen extracted from root of Astragalus membranaceus. On the basis of summarizing the pharmacological and pharmacokinetic studies of CA in recent years, we hope to provide useful information for CA about treating different diseases and to make suggestions for future research.

Areas covered: We collected relevant information (January 2014 to March 2020) on CA via the Internet database. Keywords searched includ pharmacology, pharmacokinetics and toxicology, and the number of effective references was 118. CA is a phytoestrogen with wide range of pharmacological activities. By affecting PI3K/Akt/mTOR, WDR7-7-GPR30, Rab27B-β-catenin-VEGF, etc. signaling pathway, CA showed the effect of anticancer, anti-inflammatory, anti-osteoporosis, neuroprotection, hepatoprotection, etc. Therefore, CA is prospective to be used in the treatment of many diseases.

Expert opinion: Research shows that CA has a therapeutic effect on a variety of diseases. We think CA is a promising natural medicine. Therefore, we propose that the research directions of CA in the future include the following. Carrying out clinical research trials in order to find the most suitable medicinal concentration for different diseases; Exploring the synergistic mechanism of CA in combination with other drugs; Exploring ways to increase the blood circulation concentration of CA.



中文翻译:

Calycosin:药理作用综述及应用前景

摘要

简介:毛蕊花素(CA),一种典型的从黄芪根中提取的植物雌激素。我们希望在总结近年来CA药理药代动力学研究的基础上,为CA治疗不同疾病提供有用的信息,并为今后的研究提出建议。

覆盖范围:我们通过互联网数据库收集了CA的相关信息(2014年1月至2020年3月)。检索关键词包括药理学、药代动力学和毒理学,有效参考文献118条。CA是一种药理活性范围广泛的植物雌激素。CA通过影响PI3K/Akt/mTOR、WDR7-7-GPR30、Rab27B-β-catenin-VEGF等信号通路,表现出抗癌、抗炎、抗骨质疏松、神经保护、保肝等作用。 因此, CA有望用于治疗许多疾病。

专家意见:研究表明CA对多种疾病有治疗作用。我们认为 CA 是一种很有前途的天然药物。因此,我们提出未来CA的研究方向包括以下几个方面。开展临床研究试验,为不同疾病寻找最合适的药物浓度;探索CA与其他药物联合的协同作用机制;探索提高CA血液循环浓度的方法。

更新日期:2020-12-21
down
wechat
bug