Combat sports have an intermittent nature, with mixed anaerobic and aerobic energy production. Here, we investigated whether polymorphisms that have been previously suggested as genetic markers for endurance or power phenotypes were associated with combat-sport athletic status. A total of 23 previously reported performance-related polymorphisms were examined in a Brazilian cohort of 1,129 individuals (164 combat-sport athletes and 965 controls), using a case-control association study. We found that the GABPβ1 gene (also known as NRF2) was associated with athletic status, with the minor G (rs7181866) and T (rs8031031) alleles overrepresented in athletes (P ≤ 0.003), especially among world-class competitors (P ≤ 0.0002). These findings indicate that single nucleotide polymorphisms (SNPs) within the GABPβ1 gene increase the likelihood of an individual being a combat-sport athlete, possibly due to a better mitochondrial response to intermittent exercises.

中文翻译：

---

巴西格斗运动员表现相关多态性的关联研究突出了 GABPβ1 基因的变异

格斗运动具有间歇性，混合产生无氧和有氧能量。在这里，我们调查了以前被建议作为耐力或力量表型的遗传标记的多态性是否与格斗运动的运动状态有关。使用病例对照关联研究，在巴西的 1,129 人队列（164 名格斗运动员和 965 名对照）中检查了总共 23 个先前报告的与表现相关的多态性。我们发现 GABPβ1 基因（也称为 NRF2）与运动状态有关，其中次要 G（rs7181866）和 T（rs8031031）等位基因在运动员中过多（P ≤ 0.003），尤其是在世界级运动员中（P ≤ 0.0002） ）。