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Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma
Advanced Science ( IF 14.3 ) Pub Date : 2020-12-21 , DOI: 10.1002/advs.202001175 Paolo Armanetti 1 , Anastasia Chillà 2 , Francesca Margheri 2 , Alessio Biagioni 2 , Luca Menichetti 1 , Giancarlo Margheri 3 , Fulvio Ratto 4 , Sonia Centi 4 , Francesca Bianchini 2 , Mirko Severi 5 , Rita Traversi 5 , Daniele Bani 6 , Matteo Lulli 2 , Tommaso Del Rosso 7 , Alessandra Mocali 2 , Elisabetta Rovida 2 , Mario Del Rosso 2 , Gabriella Fibbi 2 , Anna Laurenzana 2
Advanced Science ( IF 14.3 ) Pub Date : 2020-12-21 , DOI: 10.1002/advs.202001175 Paolo Armanetti 1 , Anastasia Chillà 2 , Francesca Margheri 2 , Alessio Biagioni 2 , Luca Menichetti 1 , Giancarlo Margheri 3 , Fulvio Ratto 4 , Sonia Centi 4 , Francesca Bianchini 2 , Mirko Severi 5 , Rita Traversi 5 , Daniele Bani 6 , Matteo Lulli 2 , Tommaso Del Rosso 7 , Alessandra Mocali 2 , Elisabetta Rovida 2 , Mario Del Rosso 2 , Gabriella Fibbi 2 , Anna Laurenzana 2
Affiliation
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Near infrared (NIR)‐resonant gold nanoparticles (AuNPs) hold great promise in cancer diagnostics and treatment. However, translating the theranostic potential of AuNPs into clinical applications still remains a challenge due to the difficulty to improve the efficiency and specificity of tumor delivery in vivo as well as the clearance from liver and spleen to avoid off target toxicity. In this study, endothelial colony forming cells (ECFCs) are exploited as vehicles to deliver AuNPs to tumors. It is first demonstrated that ECFCs display a great capability to intake AuNPs without losing viability, and exert antitumor activity per se. Using a human melanoma xenograft mouse model, it is next demonstrated that AuNP‐loaded ECFCs retain their capacity to migrate to tumor sites in vivo 1 day after injection and stay in the tumor mass for more than 1 week. In addition, it is demonstrated that ECFC‐loaded AuNPs are efficiently cleared by the liver over time and do not elicit any sign of damage to healthy tissue.
中文翻译：
富含 AuNP 的内皮集落形成细胞对黑色素瘤的增强抗肿瘤活性和光声成像特性
近红外 (NIR) 共振金纳米颗粒 (AuNP) 在癌症诊断和治疗方面具有广阔的前景。然而，由于难以提高体内肿瘤递送的效率和特异性以及肝脏和脾脏的清除以避免脱靶毒性，因此将 AuNP 的治疗诊断潜力转化为临床应用仍然是一个挑战。在这项研究中，内皮集落形成细胞（ECFC）被用作将 AuNP 递送至肿瘤的载体。首次证明 ECFC 具有吸收 AuNP 而不失去活力的强大能力，并发挥其本身的抗肿瘤活性。接下来使用人类黑色素瘤异种移植小鼠模型，证明负载 AuNP 的 ECFC 在注射 1 天后保留其在体内迁移到肿瘤部位的能力，并在肿瘤块中停留超过 1 周。此外，研究表明，随着时间的推移，负载 ECFC 的 AuNP 会被肝脏有效地清除，并且不会对健康组织造成任何损害。
更新日期：2021-02-17
中文翻译：
富含 AuNP 的内皮集落形成细胞对黑色素瘤的增强抗肿瘤活性和光声成像特性
近红外 (NIR) 共振金纳米颗粒 (AuNP) 在癌症诊断和治疗方面具有广阔的前景。然而，由于难以提高体内肿瘤递送的效率和特异性以及肝脏和脾脏的清除以避免脱靶毒性，因此将 AuNP 的治疗诊断潜力转化为临床应用仍然是一个挑战。在这项研究中，内皮集落形成细胞（ECFC）被用作将 AuNP 递送至肿瘤的载体。首次证明 ECFC 具有吸收 AuNP 而不失去活力的强大能力，并发挥其本身的抗肿瘤活性。接下来使用人类黑色素瘤异种移植小鼠模型，证明负载 AuNP 的 ECFC 在注射 1 天后保留其在体内迁移到肿瘤部位的能力，并在肿瘤块中停留超过 1 周。此外，研究表明，随着时间的推移，负载 ECFC 的 AuNP 会被肝脏有效地清除，并且不会对健康组织造成任何损害。
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