Flexibility in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis is an important mediator of stress resilience as it helps organisms adjust to, avoid, or compensate for acute and chronic challenges across changing environmental contexts. Glucocorticoids remain the favorite metric from medicine to conservation biology to attempt to quantify stress resilience despite the skepticism around their consistency in relation to individual health, welfare, and fitness. We suggest that a cochaperone molecule related to heat shock proteins and involved in glucocorticoid receptor activity, FKBP5, may mediate HPA flexibility and therefore stress resilience because it affects how individuals can regulate glucocorticoids and therefore capacitates their abilities to adjust phenotypes appropriately to prevailing, adverse conditions. Although the molecule is well studied in the biomedical literature, FKBP5 research in wild vertebrates is limited. In the present article, we highlight the potential major role of FKBP5 as mediator of HPA axis flexibility in response to adversity in humans and lab rodents.

中文翻译：

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FKBP5：脊椎动物如何灵活应对逆境的关键中介者

调节下丘脑-垂体-肾上腺（HPA）轴的灵活性是压力适应力的重要调节器，因为它可以帮助有机体适应，避免或补偿不断变化的环境环境中的急性和慢性挑战。糖皮质激素仍然是从医学到保护生物学的最常用指标，尽管人们怀疑它们与个体健康，福利和健康有关的一致性，但仍试图量化应激弹性。我们建议与热休克蛋白有关并参与糖皮质激素受体活性的伴侣分子FKBP5可能介导HPA的柔韧性并因此产生抗逆力，因为它影响个体调节糖皮质激素的能力，因此会影响他们根据流行的不利条件适当调节表型的能力。 。尽管在生物医学文献中对该分子进行了充分的研究，但FKBP5在野生脊椎动物中的研究仍然有限。在本文中，我们重点介绍了FKBP5作为HPA轴柔性的介质的潜在主要作用，以应对人类和实验室啮齿动物的逆境。