The immobilization of a broad‐spectrum antibiotic amikacin on macromolecules of dextran previously modified with epichlorohydrin is described. It is shown that the release of amikacin is observed only in the presence of dextranase, which is produced by bacteria. For the first time, biocomposite materials based on the Glisson capsule of the liver and the pericardium, containing a layer of grafted dextran acting as a carrier of amikacin and capable of releasing amikacin derivatives that have antibacterial activity in the case of infection, have been developed. It was found that the release rate of amikacin derivatives formed in the presence of dextranase is determined by diffusion and is inversely proportional to the squared thickness of the dextran‐containing layer on the surface of biocomposite materials. © 2020 Society of Chemical Industry

中文翻译：

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将阿米卡星固定在葡聚糖上：在细菌葡聚糖酶存在下释放抗生素的生物复合材料

描述了将广谱抗生素阿米卡星固定在事先用表氯醇修饰的葡聚糖大分子上。结果表明，仅在由细菌产生的葡聚糖酶存在下才观察到丁胺卡那霉素的释放。首次开发了基于肝脏和心包的Glisson胶囊的生物复合材料，该材料包含一层接枝的葡聚糖，可作为丁胺卡那霉素的载体，并能够在感染时释放具有抗菌活性的丁胺卡那霉素衍生物。 。发现在葡聚糖酶存在下形成的丁胺卡那霉素衍生物的释放速率是通过扩散确定的，并且与生物复合材料表面上含葡聚糖层的平方厚度成反比。©2020化学工业协会