Angiotensin II (AngII), the effector peptide of the renin angiotensin system and has an important role in regulating cardiovascular hemodynamics and structure. AngII is an important biomarker for certain diseases that are associated with cardiovascular disorders, i.e., influenza, SARS‐CoV‐2, tumors, hypertension, etc. However, AngII presents in blood in very low concentrations and they are not stable due to their reactivity, therefore spontaneous detection of AngII is a big challenge. In this study, AngII‐imprinted spongy columns (AngII‐misc) synthesized for AngII detection from human serum, and characterized by surface area measurements (BET), swelling tests, scanning electron microscopy (SEM), FTIR studies. AngII binding studies were achieved from aqueous environment and maximum binding capacity was found as 0.667 mg/g. It was calculated that the AngII‐miscs recognized AngII 8.27 and 14.25 times more selectively than competitor Angiotensin I and Vasopressin molecules. Newly produced AngII‐misc binds 60.5 pg/g AngII from crude human serum selectively. It has a great potential for spontaneous detection of AngII from human serum for direct and critical measurements in serious diseases, that is, heart attacks, SARS‐CoV‐2, etc.

中文翻译：

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用于从人血清中识别血管紧张素 (II) 的分子印迹海绵柱

血管紧张素II（AngII）是肾素血管紧张素系统的效应肽，在调节心血管血流动力学和结构方面具有重要作用。AngII 是某些与心血管疾病相关的疾病的重要生物标志物，例如流感、SARS-CoV-2、肿瘤、高血压等。然而，AngII 以非常低的浓度存在于血液中，并且由于它们的反应性而不稳定，因此自发检测 AngII 是一个很大的挑战。在这项研究中，合成了 AngII 印迹海绵柱 (AngII-misc)，用于从人血清中检测 AngII，并通过表面积测量 (BET)、溶胀测试、扫描电子显微镜 (SEM)、FTIR 研究对其进行了表征。AngII 结合研究是在水环境中进行的，发现最大结合能力为 0.667 mg/g。据计算，AngII-miscs 识别 AngII 的选择性比竞争对手血管紧张素 I 和加压素分子高 8.27 倍和 14.25 倍。新生产的 AngII-misc 选择性地结合来自粗制人血清的 60.5 pg/g AngII。它具有巨大的潜力，可以从人血清中自发检测 AngII，用于严重疾病（即心脏病发作、SARS-CoV-2 等）的直接和关键测量。