RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer’s disease,Neuropathology and Applied Neurobiology

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RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer’s disease
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2020-12-20 , DOI: 10.1111/nan.12686
You-Na Jang ₁ , HoChung Jang ₁ , Gyu Hyun Kim ₁ , Jeong-Eun Noh ₁ , Keun-A Chang ₂ , Kea Joo Lee _{1,

3}

Affiliation

Amyloid-β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer-induced synaptic and cognitive impairments in human-mutant amyloid precursor protein (APP) mouse models of Alzheimer's disease (AD).

中文翻译：

RAPGEF2 介导 3xTg-AD 阿尔茨海默病小鼠模型中寡聚 Aβ 诱导的突触丧失和认知功能障碍

淀粉样蛋白-β (Aβ) 寡聚体引发斑块和缠结病理之前的突触变性。然而，将 Aβ 寡聚体与突触病理学联系起来的信号分子仍不清楚。在这里，我们讨论了 RAPGEF2 作为一种新型信号分子在 Aβ 寡聚体诱导的阿尔茨海默病 (AD) 人类突变淀粉样前体蛋白 (APP) 小鼠模型中的突触和认知障碍中的潜在作用。

更新日期：2020-12-20

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