Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt‐loaded metabolic syndrome rats,Annals of the New York Academy of Sciences

当前位置： X-MOL 学术 › Ann. N. Y. Acad. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt‐loaded metabolic syndrome rats
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-12-19 , DOI: 10.1111/nyas.14546
Yuki Komatsu ₁ , Kiyoshi Aoyama ₁ , Mamoru Yoneda ₁ , Shogo Ito ₁ , Yusuke Sano ₁ , Yumeno Kawai ₁ , Xixi Cui ₁ , Yuichiro Yamada ₁ , Nozomi Furukawa ₁ , Katsuhide Ikeda ₁ , Kohzo Nagata ₁

Affiliation

Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metabolic syndrome (MetS). DS/obese rats were subjected to surgical removal of iBAT or sham surgery at 8 weeks of age and were provided with drinking water containing or not containing 0.3% NaCl for 4 weeks beginning at 9 weeks of age. Removal of iBAT suppressed the salt-induced exacerbation of left ventricular inflammation, fibrosis, and diastolic dysfunction, but not that of hypertension development, in DS/obese rats. Salt loading attenuated adipocyte hypertrophy but enhanced inflammation in both visceral white adipose tissue (WAT) and iBAT. Although iBAT removal did not affect visceral WAT pathology in salt-loaded DS/obese rats, it attenuated the elevation of circulating interleukin-6 levels in these animals. Downregulation of uncoupling protein-1 expression in iBAT of DS/obese rats was not affected by salt loading. Our results suggest that the conversion of iBAT to WAT-like tissue contributes to a salt-induced elevation of circulating proinflammatory cytokine levels that leads to exacerbation of cardiac pathology in this model of MetS.

中文翻译：

手术消融增白的肩胛间棕色脂肪改善盐负荷代谢综合征大鼠的心脏病理

棕色脂肪组织 (BAT) 是一种内分泌器官，有助于产热和能量消耗。我们研究了盐负荷和手术去除增白的肩胛间 BAT (iBAT) 对 DahlS.Z-Leprfa /Leprfa (DS/肥胖) 大鼠心脏和脂肪组织病理学的影响，这是一种代谢综合征 (MetS) 动物模型。DS/肥胖大鼠在 8 周龄时接受 iBAT 手术切除或假手术，并从 9 周龄开始连续 4 周提供含有或不含 0.3% NaCl 的饮用水。在 DS/肥胖大鼠中，去除 iBAT 可抑制盐诱导的左心室炎症、纤维化和舒张功能障碍恶化，但不能抑制高血压发展。盐负荷减弱了脂肪细胞肥大，但在内脏白色脂肪组织 (WAT) 和 iBAT 中增强了炎症。尽管 iBAT 去除不影响盐负荷 DS/肥胖大鼠的内脏 WAT 病理，但它减弱了这些动物中循环白细胞介素 6 水平的升高。DS/肥胖大鼠 iBAT 中解偶联蛋白-1 表达的下调不受盐负荷的影响。我们的结果表明，iBAT 向 WAT 样组织的转化有助于盐诱导的循环促炎细胞因子水平升高，从而导致该 MetS 模型中的心脏病变恶化。

更新日期：2020-12-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11