Abstract

The present paper deals with the study of condensation reaction of aniline with acetone under electrospray ionization (ESI) conditions . An experimental setup is described for conducting reactions under ESI conditions with a possibility of the accumulation of reaction products. The aniline and acetone condensation products were analyzed by gas chromatography–mass spectrometry. Spraying this mixture with high concentration of formic acid, results in the formation of N-phenylformamide, N,N'-diphenylmethaneimidamide, and 1,2-dihydro-2,2,4-trimethylquinoline; the last one is the only product of the reaction of aniline with acetone. Thus, the Schiff base formation reaction radically changes its direction. The results obtained using the proposed experimental setup open up new prospects both for studying chemical reactions in charged microdroplets and for the use of ESI as a preparative method for the synthesis of organic compounds.

中文翻译：

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电喷雾电离条件下苯胺与丙酮缩合反应的研究

摘要

本文主要研究电喷雾电离（ESI）条件下苯胺与丙酮的缩合反应。描述了一种用于在ESI条件下进行反应并可能积聚反应产物的实验装置。通过气相色谱-质谱法分析苯胺和丙酮的缩合产物。用高浓度的甲酸喷洒该混合物会导致形成N-苯基甲酰胺N，N'-二苯基甲烷亚酰胺，和1,2-二氢-2,2,4-三甲基喹啉；最后一个是苯胺与丙酮反应的唯一产物。因此，席夫碱形成反应从根本上改变了其方向。使用提议的实验装置获得的结果为研究带电微滴中的化学反应以及将ESI用作有机化合物合成的制备方法开辟了新的前景。