The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved multiple strategies to evade innate immune response to facilitate viral replication, transmission, and pathogenesis. This review summarizes the recent progresses on SARS-CoV-2 proteins that antagonize host IFN-I production and/or signaling. These progresses have provided knowledge for new vaccine and antiviral development to prevent and control COVID-19.

中文翻译：

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严重急性呼吸综合征冠状病毒2对I型干扰素的拮抗作用

2019 年冠状病毒病 (COVID-19) 大流行是由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的，需要紧急研究 SARS-CoV-2 感染和宿主免疫反应的分子机制。I 型干扰素 (IFN-I) 是宿主先天免疫系统的关键组成部分，负责在感染早期消除病毒。相比之下，SARS-CoV-2 已经进化出多种策略来逃避先天免疫反应，以促进病毒复制、传播和发病机制。本综述总结了对抗宿主 IFN-I 产生和/或信号传导的 SARS-CoV-2 蛋白的最新进展。这些进展为预防和控制 COVID-19 的新疫苗和抗病毒药物开发提供了知识。