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The role of repetitive transcranial magnetic stimulation for enhancing the quality of life in Parkinson's Disease: A systematic review
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-11-01 , DOI: 10.4103/aian.aian_70_20 Ashima Nehra 1 , Priya S Sharma 1 , Avneesh Narain 1 , Amit Kumar 2 , Swati Bajpai 3 , Roopa Rajan 2 , Nand Kumar 4 , Vinay Goyal 5 , Achal K Srivastava 2
Background: Parkinson's disease (PD) is a neurodegenerative disorder which greatly affects patients' quality of life. Despite an exponential increase in PD cases, not much attention has been paid to enhancing their quality of life (QoL). Thus, this systematic review aims to summarize the available literature for the role of repetitive transcranial magnetic stimulation (rTMS) intervention to improve QoL of PD patients. Methods: Literature review was carried out using PubMed, Embase, Web of Science and Scopus databases. The key search words were, “rTMS AND Parkinson AND QoL”, “rTMS AND Parkinson AND Quality of Life”. Cochrane Collaboration software Revman 5.3 was used to assess the quality of studies. Results: Over 707 studies were identified out of which 5 studies were included which consisted of 160 subjects, 89 male and 71 female, with mean age of 65.04 years. PD type varied from idiopathic PD, rigid, akinetic, tremor dominant to mixed type. The overall risk of bias across the studies was low and unclear with high risk of bias in incomplete outcome data domain in one study. Conclusions: The efficacy of rTMS as an adjunct intervention to enhance QoL of PD patients is uncertain due to dire lack of research in this area. The findings of the present review would help researchers conduct a well-defined, randomized, controlled trial by overcoming the present limitations associated with rTMS intervention to improve QoL of PD patients.
中文翻译：
重复经颅磁刺激在提高帕金森病患者生活质量中的作用：系统评价
背景：帕金森病（PD）是一种严重影响患者生活质量的神经退行性疾病。尽管 PD 病例呈指数增长，但并未对提高他们的生活质量 (QoL) 给予太多关注。因此，本系统评价旨在总结现有文献，说明重复经颅磁刺激 (rTMS) 干预在改善 PD 患者生活质量方面的作用。方法：使用 PubMed、Embase、Web of Science 和 Scopus 数据库进行文献综述。关键词是“ rTMS AND Parkinson AND QoL ”、“ rTMS AND Parkinson AND Quality of Life ”。Cochrane Collaboration 软件 Revman 5.3用于评估研究质量。结果：确定了超过 707 项研究，其中包括 5 项研究，包括 160 名受试者，89 名男性和 71 名女性，平均年龄为 65.04 岁。PD类型从特发性PD、僵硬型、运动障碍型、震颤主导型到混合型不等。在一项研究中，研究的总体偏倚风险较低且不明确，不完整结果数据域的偏倚风险较高。结论： rTMS 作为辅助干预以提高 PD 患者生活质量的效果尚不确定，因为这方面的研究非常缺乏。本综述的结果将帮助研究人员通过克服目前与 rTMS 干预相关的限制来改善 PD 患者的生活质量，从而进行定义明确的随机对照试验。
更新日期：2020-12-20
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-11-01 , DOI: 10.4103/aian.aian_70_20 Ashima Nehra 1 , Priya S Sharma 1 , Avneesh Narain 1 , Amit Kumar 2 , Swati Bajpai 3 , Roopa Rajan 2 , Nand Kumar 4 , Vinay Goyal 5 , Achal K Srivastava 2
Affiliation
Background: Parkinson's disease (PD) is a neurodegenerative disorder which greatly affects patients' quality of life. Despite an exponential increase in PD cases, not much attention has been paid to enhancing their quality of life (QoL). Thus, this systematic review aims to summarize the available literature for the role of repetitive transcranial magnetic stimulation (rTMS) intervention to improve QoL of PD patients. Methods: Literature review was carried out using PubMed, Embase, Web of Science and Scopus databases. The key search words were, “rTMS AND Parkinson AND QoL”, “rTMS AND Parkinson AND Quality of Life”. Cochrane Collaboration software Revman 5.3 was used to assess the quality of studies. Results: Over 707 studies were identified out of which 5 studies were included which consisted of 160 subjects, 89 male and 71 female, with mean age of 65.04 years. PD type varied from idiopathic PD, rigid, akinetic, tremor dominant to mixed type. The overall risk of bias across the studies was low and unclear with high risk of bias in incomplete outcome data domain in one study. Conclusions: The efficacy of rTMS as an adjunct intervention to enhance QoL of PD patients is uncertain due to dire lack of research in this area. The findings of the present review would help researchers conduct a well-defined, randomized, controlled trial by overcoming the present limitations associated with rTMS intervention to improve QoL of PD patients.
中文翻译：
重复经颅磁刺激在提高帕金森病患者生活质量中的作用：系统评价
背景：帕金森病（PD）是一种严重影响患者生活质量的神经退行性疾病。尽管 PD 病例呈指数增长，但并未对提高他们的生活质量 (QoL) 给予太多关注。因此，本系统评价旨在总结现有文献，说明重复经颅磁刺激 (rTMS) 干预在改善 PD 患者生活质量方面的作用。方法：使用 PubMed、Embase、Web of Science 和 Scopus 数据库进行文献综述。关键词是“ rTMS AND Parkinson AND QoL ”、“ rTMS AND Parkinson AND Quality of Life ”。Cochrane Collaboration 软件 Revman 5.3用于评估研究质量。结果：确定了超过 707 项研究，其中包括 5 项研究，包括 160 名受试者，89 名男性和 71 名女性，平均年龄为 65.04 岁。PD类型从特发性PD、僵硬型、运动障碍型、震颤主导型到混合型不等。在一项研究中，研究的总体偏倚风险较低且不明确，不完整结果数据域的偏倚风险较高。结论： rTMS 作为辅助干预以提高 PD 患者生活质量的效果尚不确定，因为这方面的研究非常缺乏。本综述的结果将帮助研究人员通过克服目前与 rTMS 干预相关的限制来改善 PD 患者的生活质量，从而进行定义明确的随机对照试验。
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