Catalytic Principles from Natural Enzymes and Translational Design Strategies for Synthetic Catalysts,ACS Central Science

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Catalytic Principles from Natural Enzymes and Translational Design Strategies for Synthetic Catalysts
ACS Central Science ( IF 12.7 ) Pub Date : 2020-12-19 , DOI: 10.1021/acscentsci.0c01556
Wan-Lu Li _{1,

2} , Teresa Head-Gordon _{1,

2}

Affiliation

As biocatalysts, enzymes are characterized by their high catalytic efficiency and strong specificity but are relatively fragile by requiring narrow and specific reactive conditions for activity. Synthetic catalysts offer an opportunity for more chemical versatility operating over a wider range of conditions but currently do not reach the remarkable performance of natural enzymes. Here we consider some new design strategies based on the contributions of nonlocal electric fields and thermodynamic fluctuations to both improve the catalytic step and turnover for rate acceleration in arbitrary synthetic catalysts through bioinspired studies of natural enzymes. With a focus on the enzyme as a whole catalytic construct, we illustrate the translational impact of natural enzyme principles to synthetic enzymes, supramolecular capsules, and electrocatalytic surfaces.

中文翻译：

天然酶的催化原理和合成催化剂的转化设计策略

作为生物催化剂，酶的特征在于它们的高催化效率和强特异性，但由于需要狭窄和特定的反应条件才能使酶相对脆弱。合成催化剂为在更大范围的条件下操作提供更多化学多功能性提供了机会，但目前还不能达到天然酶的出色性能。在这里，我们考虑基于非局部电场和热力学波动的贡献而提出的一些新的设计策略，以通过自然酶的生物启发研究来改善任意合成催化剂中速率加速的催化步骤和转化率。着眼于整个酶的催化结构，我们说明了天然酶原理对合成酶，超分子胶囊，

更新日期：2021-01-27

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