Probing and Tuning the Permeability of Polymersomes,ACS Central Science

当前位置： X-MOL 学术 › ACS Cent. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Probing and Tuning the Permeability of Polymersomes
ACS Central Science ( IF 12.7 ) Pub Date : 2020-12-18 , DOI: 10.1021/acscentsci.0c01196
Alisha J. Miller ₁ , Amanda K. Pearce ₁ , Jeffrey C. Foster ₁ , Rachel K. O’Reilly ₁

Affiliation

Polymersomes are a class of synthetic vesicles composed of a polymer membrane surrounding an aqueous inner cavity. In addition to their overall size, the thickness and composition of polymersome membranes determine the range of potential applications in which they can be employed. While synthetic polymer chemists have made great strides in controlling polymersome membrane parameters, measurement of their permeability to various analytes including gases, ions, organic molecules, and macromolecules remains a significant challenge. In this Outlook, we compare the general methods that have been developed to quantify polymersome membrane permeability, focusing in particular on their capability to accurately measure analyte flux. In addition, we briefly highlight strategies to control membrane permeability. Based on these learnings, we propose a set of criteria for designing future methods of quantifying membrane permeability such that the passage of a variety of molecules into and out of their lumens can be better understood.

中文翻译：

探测和调整聚合物小体的渗透性

聚合物囊泡是一类合成囊泡，由围绕水性内腔的聚合物膜组成。除了它们的整体尺寸之外，聚合物小体膜的厚度和组成决定了它们可以应用的潜在应用范围。尽管合成高分子化学家在控制聚合物小体膜参数方面取得了长足的进步，但测量其对各种分析物（包括气体，离子，有机分子和大分子）的渗透性仍然是一项重大挑战。在本《展望》中，我们比较了已开发出的用于量化多聚体膜通透性的一般方法，特别是侧重于其准确测量分析物通量的能力。此外，我们简要介绍了控制膜渗透性的策略。根据这些经验，

更新日期：2021-01-27

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11