Capture and Kill: Selective Eradication of Target Bacteria by a Flexible Bacteria-Imprinted Chip,ACS Biomaterials Science & Engineering

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Capture and Kill: Selective Eradication of Target Bacteria by a Flexible Bacteria-Imprinted Chip
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-18 , DOI: 10.1021/acsbiomaterials.0c01568
Liwei Hui ₁ , Jun Chen ₂ , Parmila Kafley ₁ , Haitao Liu ₁

Affiliation

This paper reports an antibacterial chip that can selectively capture bacteria and kill them using low-voltage DC electricity. We prepared a bacteria-imprinted, flexible PDMS chip that can separate target bacteria from suspensions with high selectivity. The chip contained integrated electrodes that can kill the captured bacteria within 10 min by applying a low DC voltage. The used chip could be easily regenerated by solution immersion. Meanwhile, the PDMS chip showed good biocompatibility and inhibited adhesion of human blood cells. Our work points to a new strategy to address pathogenic bacterial contamination and infection.

中文翻译：

捕获和杀死：通过柔性细菌印迹芯片选择性消除目标细菌

本文报道了一种抗菌芯片，该芯片可以选择性地捕获细菌并使用低压直流电杀死它们。我们准备了一种细菌印迹的柔性PDMS芯片，该芯片可以高选择性地从悬浮液中分离目标细菌。该芯片包含集成电极，可通过施加低直流电压在10分钟内杀死捕获的细菌。通过溶液浸没可以很容易地再生用过的芯片。同时，PDMS芯片显示出良好的生物相容性并抑制了人类血细胞的粘附。我们的工作指出了解决病原细菌污染和感染的新策略。

更新日期：2021-01-11

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