Supramolecular Chirality in Metal–Organic Complexes,Accounts of Chemical Research

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Supramolecular Chirality in Metal–Organic Complexes
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-12-18 , DOI: 10.1021/acs.accounts.0c00604
Jinqiao Dong ₁ , Yan Liu ₁ , Yong Cui ₁

Affiliation

Chirality is a pervasive structural feature of nature and crucial to the organization and function of nearly all biological systems. At the molecular level, the biased availability of enantiomers in nucleic and amino acids forms the basis for asymmetry. However, chirality expression in natural systems remains complex and intriguing across differing length scales. The translation of chirality toward synthetic systems therefore not only is crucial for fundamental understanding but also may address key challenges in biochemistry and pharmacology. From a structural viewpoint, a fascinating class of cavity-containing supramolecular assemblies, homochiral metal–organic complexes (MOCs), provides a good opportunity to study enantioselective processes. Chiral MOCs are constructed by coordination-driven self-assembly, wherein relatively simple molecular precursors are allowed to assemble into structurally well-defined two-dimensional (2D) metallacycles or 3D metallacages spontaneously with complex and varied functions. These aesthetically appealing structures present nanocavities with space-restricted chiral microenvironments capable of interacting distinctly with molecularly asymmetric guests, which is highly beneficial to explore the relay of chiral information from locally chiral molecules to globally chiral supramolecules, which is a significant challenge.

中文翻译：

金属-有机配合物中的超分子手性

手性是自然的普遍结构特征，对几乎所有生物系统的组织和功能都至关重要。在分子水平上，核酸和氨基酸中对映异构体的可利用性偏倚是不对称的基础。然而，自然系统中的手性表达在不同的长度尺度上仍然是复杂且有趣的。因此，手性向合成系统的转化不仅对于基本理解至关重要，而且还可以解决生物化学和药理学方面的关键挑战。从结构的角度来看，一类引人入胜的含腔超分子组装体，同手性金属-有机配合物（MOC），为研究对映选择性过程提供了一个很好的机会。手性MOC是通过协调驱动的自组装构建的，其中相对简单的分子前体被允许自发地组装成结构复杂的二维（2D）金属环或3D金属环，具有复杂而变化的功能。这些具有美学吸引力的结构为纳米腔体提供了空间受限的手性微环境，能够与分子不对称的客体清楚地相互作用，这对于探索手性信息从局部手性分子到全局手性超分子的传递非常有利。

更新日期：2021-01-05

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