Over two thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.

中文翻译：

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肥胖引起的老年人认知障碍：微血管视角


在美国，超过三分之二的 65 岁及以上老年人肥胖或超重。流行病学数据显示老年人的肥胖程度与认知功能障碍之间存在关联。在这篇综述中，考虑了微血管机制的病理生理学作用，包括内皮功能受损和神经血管耦合反应、微血管稀疏和血脑屏障破坏在老年肥胖认知障碍的发生中的作用。讨论了脂肪源性因子以及衰老的基本细胞和分子机制对加剧肥胖引起的脑微血管损伤和衰老认知能力下降的潜在贡献。