The emergence of antibiotic‐resistant bacteria (ARBs) has become a threat to the aquatic industry. Virulent bacterial spp. namely Aeromonas hydrophila, A. veronii, Pseudomonas fluorescens and P. aeruginosa that were isolated from Nile tilapia (Oreochromis niloticus) and grey mullet (Mugil cephalus) were collected from freshwater fish farms at three different sites, and their associated antibiotic‐resistant genes (ARBs) were further characterized. The ARGs for sulphonamide and tetracycline were the most prevalent ones. Out of 50 O. niloticus and 50 M. cephalus, A. hydrophila (16.5 ± 5.5 and 11 ± 1.0 respectively) and P. aeruginosa (16 ± 1.0 and 12.5 ± 2.5 respectively) had significantly higher infection rates. At site 3, O. niloticus and M. cephalus showed severe lesions in the hepatic tissues which had higher residues of iron (Fe, 1238.3–1250.0 µg/g) and zinc (Zn, 940.0–078.0 µg/g) compared with sites 1 and 2. The severity of hepatic tissue lesions was associated with bacterial infection and heavy metal residues, and also the presence of ARGs was associated with histopathological alterations of the hepatic tissues. It was concluded that ARGs (sulphonamide and tetracycline) could be developed in bacteria isolated from fish, which subjected to heavy metal pollution (Fe, Mn and Zn).

中文翻译：

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淡水养鱼场中抗生素耐药菌的流行

抗生素抗性细菌（ARBs）的出现已对水产养殖业构成威胁。剧毒细菌。即嗜水，A.维罗纳，荧光假单胞菌和铜绿假单胞菌从尼罗罗非鱼（分离即尼罗罗非鱼）和鲻鱼（鲻从淡水养殖场收集在三个不同的位点），以及它们的相关联的抗生素抗性基因（ ARBs）进一步表征。磺胺类药物和四环素类药物的ARGs最普遍。出50个的尼罗和50个M.法罗斯，嗜水气单（分别为16.5±5.5和11±1.0）和铜绿假单胞菌（分别为16±1.0和12.5±2.5）具有较高的感染率。在点3，尼罗和M.法罗斯显示出严重的病变部位在肝组织其具有铁的高残基（铁，1238.3-1250.0微克/克）和锌（Zn，940.0-078.0微克/克）与位点1相比2.肝组织损伤的严重程度与细菌感染和重金属残留有关，并且ARG的存在也与肝组织的组织病理学改变有关。可以得出结论，ARG（磺酰胺和四环素）可以在从鱼类中分离出来的细菌中产生，这些细菌受到重金属（Fe，Mn和Zn）的污染。